Resultados da pesquisa - (( j small compound can now ) OR ((( j nayl clamp j non ) OR ( j nary (cam OR com) c now ))))

Pesquisas alternativas:
compound » compounds (Expandir a Pesquisa)
nayl » nayla (Expandir a Pesquisa), natl (Expandir a Pesquisa), nail (Expandir a Pesquisa)
nary » mary (Expandir a Pesquisa), vary (Expandir a Pesquisa), gary (Expandir a Pesquisa)

1

Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin

Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin

Por Hall, Jason C., Marlow, Laura A., Mathias, Adam C., Dawson, Louis K., Durham, William F., Meshaw, Kenneth A., Mullin, Robert J., Synnott, Aidan J., Small, Daniel L., Krishna, Murli, von Hoff, Daniel, Schüler, Julia, Hart, Steven N., Couch, Fergus J., Colon-Otero, Gerardo, Copland, John A.
Publicado no J Transl Med (2016)

“... cells developed from their liver metastasis. We now report the characterization of a patient derived...”
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2

Small Molecule Screen for Candidate Antimalarials Targeting Plasmodium Kinesin-5

Small Molecule Screen for Candidate Antimalarials Targeting Plasmodium Kinesin-5

Por Liu, Liqiong, Richard, Jessica, Kim, Sunyoung, Wojcik, Edward J.
Publicado em 2014

“..., resulting in over a million deaths annually. Malaria parasites now show measured resistance to all currently...”
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3

A paradigm for drug discovery employing encoded combinatorial libraries.

A paradigm for drug discovery employing encoded combinatorial libraries.

Por Burbaum, J J, Ohlmeyer, M H, Reader, J C, Henderson, I, Dillard, L W, Li, G, Randle, T L, Sigal, N H, Chelsky, D, Baldwin, J J
Publicado em 1995

“...Very large combinatorial libraries of small molecules on solid supports can now be synthesized...”
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4

A Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor Microplates

A Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor Microplates

Por Chan, Leo L., Lidstone, Erich A., Finch, Kristin E., Heeres, James T., Hergenrother, Paul J., Cunningham, Brian T.
Publicado em 2009

“... in pharmaceutical discovery programs. It is now recognized that a substantial fraction of small molecules exhibit...”
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5

Antiprotozoal Effect of Saponins in the Rumen Can Be Enhanced by Chemical Modifications in Their Structure

Antiprotozoal Effect of Saponins in the Rumen Can Be Enhanced by Chemical Modifications in Their Structure

Por Ramos-Morales, Eva, de la Fuente, Gabriel, Duval, Stephane, Wehrli, Christof, Bouillon, Marc, Lahmann, Martina, Preskett, David, Braganca, Radek, Newbold, Charles J.
Publicado no Front Microbiol (2017)

“... moiety of the saponin with small polar residues would produce sapogen-like analogs which might...”
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6

Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library

Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library

Por Reilley, Kate J., Giulianotti, Marc, Dooley, Colette T., Nefzi, Adel, McLaughlin, Jay P., Houghten, Richard A.
Publicado em 2010

“... libraries can be screened directly in vivo to identify individual compounds, potentially accelerating...”
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7

“From Large-Scale Collections to the Potential Use of Genomic Techniques for Supply of Drug Candidates”

“From Large-Scale Collections to the Potential Use of Genomic Techniques for Supply of Drug Candidates”

Por David J. Newman
Publicado em 2018-10-01

“...The initial sources of marine-derived compounds that on a small scale exhibited interesting...”
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8

Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport

Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport

Por Ambrus, Géza, Whitby, Landon R., Singer, Eric L., Trott, Oleg, Choi, Euna, Olson, Arthur J., Boger, Dale L., Gerace, Larry
Publicado em 2010

“... of the exportin CRM1, has proved to be an invaluable tool for cell biologists, but up to now no small molecule...”
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9

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity

Por Tardif, Steve, Madamidola, Oladipo A., Brown, Sean G., Frame, Lorna, Lefièvre, Linda, Wyatt, Paul G., Barratt, Christopher L.R., Martins Da Silva, Sarah J.
Publicado no Hum Reprod (2014)

“...STUDY QUESTION: Can we identify compound(s) with reported phosphodiesterase inhibitor (PDEI...”
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10

Identification of tumorigenic and therapeutically actionable mutations in transplantable mouse tumor cells by exome sequencing

Identification of tumorigenic and therapeutically actionable mutations in transplantable mouse tumor cells by exome sequencing

Por Bhadury, J, López, M D, Muralidharan, S V, Nilsson, L M, Nilsson, J A
Publicado em 2013

“.... Furthermore, their use as tools is now enhanced as they can be used to create syngenic transplant models...”
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11

High content screen for identifying small-molecule LC3B-localization modulators in a renal cancer cell line

High content screen for identifying small-molecule LC3B-localization modulators in a renal cancer cell line

Por Kolla, Likhitha, Heo, David S., Rosenberg, Daniel P., Barlow, Sara A., Maximova, Anna A., Cassio, Emily E., Buchser, William J.
Publicado no Sci Data (2018)

“... in vitro. Here, we describe a high content screen from which we identified small chemical compounds...”
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12

Inhibitors of SARS-CoV-2 PLpro

Inhibitors of SARS-CoV-2 PLpro

Por Dale J. Calleja, Dale J. Calleja, Guillaume Lessene, Guillaume Lessene, Guillaume Lessene, David Komander, David Komander
Publicado em 2022-04-01

“... there are now ∼30 distinct crystal structures with small molecule inhibitors bound in a surprising number...”
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13

Development of a Unique Small Molecule Modulator of CXCR4

Development of a Unique Small Molecule Modulator of CXCR4

Por Liang, Zhongxing, Zhan, Weiqiang, Zhu, Aizhi, Yoon, Younghyoun, Lin, Songbai, Sasaki, Maiko, Klapproth, Jan-Michael A., Yang, Hua, Grossniklaus, Hans E., Xu, Jianguo, Rojas, Mauricio, Voll, Ronald J., Goodman, Mark M., Arrendale, Richard F., Liu, Jin, Yun, C. Chris, Snyder, James P., Liotta, Dennis C., Shim, Hyunsuk
Publicado em 2012

“... is now beginning to emerge from the pipeline. CXC chemokine receptor-4 (CXCR4) and its ligand stromal...”
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14

Brain imaging measurements of fibrillar amyloid‐β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele

Brain imaging measurements of fibrillar amyloid‐β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE...

Por Ghisays, Valentina, Goradia, Dhruman D., Protas, Hillary, Bauer, Robert J., Devadas, Vivek, Tariot, Pierre N., Lowe, Val J., Knopman, David S., Petersen, Ronald C., Jack, Clifford R., Caselli, Richard J., Su, Yi, Chen, Kewei, Reiman, Eric M.
Publicado no Alzheimers Dement (2020)

“... range. METHODS: We analyzed (11)C Pittsburgh compound B (Aβ) positron emission tomography (PET...”
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15

Targeting HCV Entry For Development of Therapeutics

Targeting HCV Entry For Development of Therapeutics

Por Jeffrey F. McKelvy, Flossie Wong-Staal, Andrew J. Syder
Publicado em 2010-08-01

“...Recent progress in defining the molecular mechanisms of Hepatitis C Virus (HCV) entry affords...”
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16

Targeting HCV Entry For Development of Therapeutics

Targeting HCV Entry For Development of Therapeutics

Por Wong-Staal, Flossie, Syder, Andrew J., McKelvy, Jeffrey F.
Publicado em 2010

“...Recent progress in defining the molecular mechanisms of Hepatitis C Virus (HCV) entry affords...”
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17

A luciferase lysis assay reveals in vivo malignant cell sensitization by phosphoantigen prodrugs

A luciferase lysis assay reveals in vivo malignant cell sensitization by phosphoantigen prodrugs

Por Li, Jin, Lentini, Nicholas A., Wiemer, David F., Wiemer, Andrew J.
Publicado no Biochem Pharmacol (2019)

“...Human Vγ9Vδ2 T cells respond to small phosphorus-containing compounds, often called phosphoantigens...”
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18

Interactive online application for the prediction, ranking and prioritisation of drug targets in Schistosoma haematobium

Interactive online application for the prediction, ranking and prioritisation of drug targets in Schistosoma haematobium

Por Stroehlein, Andreas J., Gasser, Robin B., Hall, Ross S., Young, Neil D.
Publicado no Parasit Vectors (2018)

“... that can now be evaluated using functional genomics tools and/or small molecules, to establish whether...”
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19

Quantitation and visualization of alkyl deoxynucleosides in the DNA of mammalian cells by monoclonal antibodies.

Quantitation and visualization of alkyl deoxynucleosides in the DNA of mammalian cells by monoclonal antibodies.

Por Adamkiewicz, J, Eberle, G, Huh, N, Nehls, P, Rajewsky, M F
Publicado em 1985

“..., in combination with radio- and enzyme-immunoassays, or with "immuno-slot-blot" techniques, now permit...”
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20

Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei

Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei

Por Begley, Darren W., Hartley, Robert C., Davies, Douglas R., Edwards, Thomas E., Leonard, Jess T., Abendroth, Jan, Burris, Courtney A., Bhandari, Janhavi, Myler, Peter J., Staker, Bart L., Stewart, Lance J.
Publicado em 2011

“... structural genomics with ligand-bound structure data which can serve as a blueprint for structure-based drug...”
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