Resultados da pesquisa - (( j nat comp can now ) OR ((( _ natl clamp a non ) OR ( j sst nam (dina OR din) ngoc ))))

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Patch-clamp recording of amino acid-activated responses in "organotypic" slice cultures.

Por Llano, I, Marty, A, Johnson, J W, Ascher, P, Gähwiler, B H
Publicado em 1988

“...Patch-clamp recording techniques were used to study the properties of amino acid-activated channels...”
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Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1

Por Gorraitz, Edurne, Hirayama, Bruce A., Paz, Aviv, Wright, Ernest M., Loo, Donald D. F.
Publicado no Proc Natl Acad Sci U S A (2017)

“... that external Na(+) binding opened a large aqueous vestibule (600 Å(3)) leading to the sugar-binding site...”
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Unique properties of non-N-methyl-D-aspartate excitatory responses in cultured purkinje neurons.

Por Joels, M, Yool, A J, Gruol, D L
Publicado em 1989

“... a response often exceeding 1 min in duration, which consists of several phases: rapid initial...”
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The diabetogenic effects of glucocorticoids are more pronounced in low- than in high-insulin responders.

Por Wajngot, A, Giacca, A, Grill, V, Vranic, M, Efendic, S
Publicado em 1992

“... conditions and during glucose infusion of 2 mg.kg-1.min-1, and insulin response during hyperglycemic clamp...”
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Construction of a high-affinity receptor site for dihydropyridine agonists and antagonists by single amino acid substitutions in a non-l-type Ca(2+) channel

Por Hockerman, Gregory H., Peterson, Blaise Z., Sharp, Elizabeth, Tanada, Timothy N., Scheuer, Todd, Catterall, William A.
Publicado em 1997

“... binding and action, we constructed a high-affinity DHP receptor site by substituting a total of nine amino...”
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Latent N-methyl-D-aspartate receptors in the recurrent excitatory pathway between hippocampal CA1 pyramidal neurons: Ca(2+)-dependent activation by blocking A1 adenosine receptors.

Por Klishin, A, Tsintsadze, T, Lozovaya, N, Krishtal, O
Publicado em 1995

“...When performed at increased external [Ca2+]/[Mg2+] ratio (2.5 mM/0.5 mM), temporary block of A1...”
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Activation of heteromeric G protein-gated inward rectifier K(+) channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons

Por Ehrengruber, Markus U., Doupnik, Craig A., Xu, Youfeng, Garvey, Justine, Jasek, Mark C., Lester, Henry A., Davidson, Norman
Publicado em 1997

“..., GIRK2, GIRK4, and the serotonin 1A receptor were constructed. Typical GIRK currents could be activated...”
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PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels

Por Kim, Robin Y., Pless, Stephan A., Kurata, Harley T.
Publicado no Proc Natl Acad Sci U S A (2017)

“...Retigabine (RTG) is a first-in-class antiepileptic drug that suppresses neuronal excitability...”
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Citrate modulates the regulation by Zn2+ of N-methyl-D-aspartate receptor-mediated channel current and neurotransmitter release.

Por Westergaard, N, Banke, T, Wahl, P, Sonnewald, U, Schousboe, A
Publicado em 1995

“... electrophysiologically by voltage clamp at a holding potential of -80 mV. It was found that citrate as well as EDTA could...”
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Purified unitary kainate/alpha-amino-3-hydroxy-5-methylisooxazole-propionate (AMPA) and kainate/AMPA/N-methyl-D-aspartate receptors with interchangeable subunits.

Por Henley, J M, Ambrosini, A, Rodriguez-Ithurralde, D, Sudan, H, Brackley, P, Kerry, C, Mellor, I, Abutidze, K, Usherwood, P N, Barnard, E A
Publicado em 1992

“... amino acid agonist specificity within one protein oligomer). The first is a unitary non-N-methyl-D...”
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Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy

Por Pritchard, Harry A. T., Pires, Paulo W., Yamasaki, Evan, Thakore, Pratish, Earley, Scott
Publicado no Proc Natl Acad Sci U S A (2018)

“... mice. Patch-clamp electrophysiological recordings indicated a corresponding increase in Ca(2...”
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Somatostatin depresses excitability in neurons of the solitary tract complex through hyperpolarization and augmentation of IM, a non-inactivating voltage-dependent outward current blocked by muscarinic...

Por Jacquin, T, Champagnat, J, Madamba, S, Denavit-Saubié, M, Siggins, G R
Publicado em 1988

“.... These data suggest that somatostatin receptors regulate a K+ conductance. In voltage-clamp studies...”
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Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus.

Por Rothman, D L, Magnusson, I, Cline, G, Gerard, D, Kahn, C R, Shulman, R G, Shulman, G I
Publicado em 1995

“... is the major cause of insulin resistance in patients with non-insulin-dependent diabetes mellitus (NIDDM...”
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Non–Ca(2+)-conducting Ca(2+) channels in fish skeletal muscle excitation-contraction coupling

Por Schredelseker, Johann, Shrivastav, Manisha, Dayal, Anamika, Grabner, Manfred
Publicado em 2010

“...-specific isoforms of RyR1. We further show that non-Ca(2+) conductivity of both Ca(V)1.1α(1S) isoforms is a...”
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Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel

Por Clayton, Gina M., Altieri, Steve, Heginbotham, Lise, Unger, Vinzenz M., Morais-Cabral, João H.
Publicado em 2008

“... channel. The structure showed how the S1–S4 domain and its associated linker can serve as a clamp...”
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Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors.

Por Mayer, M L, Vyklicky, L
Publicado em 1989

“...) did not show appreciable desensitization. Responses to L-glutamate and 5-Br-willardine (a potent non...”
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Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels.

Por Rorsman, P, Arkhammar, P, Bokvist, K, Hellerström, C, Nilsson, T, Welsh, M, Welsh, N, Berggren, P O
Publicado em 1989

“...Fetal pancreatic beta cells demonstrate a deficient insulin release in response to glucose...”
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Single-channel currents trigger action potentials in small cultured hippocampal neurons.

Por Johansson, S, Arhem, P
Publicado em 1994

“... molecules can be used as a mechanism for stochastic triggering of spontaneous impulses in mammalian central...”
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Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.

Por Younkin, D P, Tang, C M, Hardy, M, Reddy, U R, Shi, Q Y, Pleasure, S J, Lee, V M, Pleasure, D
Publicado em 1993

“...Glutamate receptor (GluR) channels are responsible for a number of fundamental properties...”
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Isolated-patch recording from liposomes containing functionally reconstituted chloride channels from Torpedo electroplax.

Por Tank, D W, Miller, C, Webb, W W
Publicado em 1982

“... a glass micropipette to the surface of these large liposomes, and single bilayer "patches...”
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