Resultados da pesquisa - (( j nart camp can non ) OR ((( 3 m.nail alp can new ) OR ( 1 small compound a non ))))

Pesquisas alternativas:
nart » nacrt (Expandir a Pesquisa), nat (Expandir a Pesquisa), nar (Expandir a Pesquisa)
camp » cam (Expandir a Pesquisa), cap (Expandir a Pesquisa), came (Expandir a Pesquisa)
m.nail » m.natl (Expandir a Pesquisa), m.neil (Expandir a Pesquisa), m.nair (Expandir a Pesquisa)
compound » compounds (Expandir a Pesquisa)

181

Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase

Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase

Por Mattila, Elina, Marttila, Heidi, Sahlberg, Niko, Kohonen, Pekka, Tähtinen, Siri, Halonen, Pasi, Perälä, Merja, Ivaska, Johanna
Publicado em 2010

“... weight compounds. METHODS: We developed a high-throughput compatible assay to analyse activity...”
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182

Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract

Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract

Por Agrawal, Smriti A., Anand, Deepti, Siddam, Archana D., Kakrana, Atul, Dash, Soma, Scheiblin, David A., Dang, Christine A., Terrell, Anne M., Waters, Stephanie M., Singh, Abhyudai, Motohashi, Hozumi, Yamamoto, Masayuki, Lachke, Salil A.
Publicado no Hum Genet (2015)

“... are associated with cataracts in human (GSTO1, MGST1, SC4MOL, UCHL1) or mouse (Aldh3a1, Crygf, Hspb1, Pcbd1...”
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183

Configurational Reassignment and Improved Preparation of the Competitive IL-6 Receptor Antagonist 20R,21R-Epoxyresibufogenin-3-formate

Configurational Reassignment and Improved Preparation of the Competitive IL-6 Receptor Antagonist 20R,21R-Epoxyresibufogenin-3-formate

Por Boos, Terrence L., Cheng, Kejun, Greiner, Elisabeth, Deschamps, Jeffrey R., Jacobson, Arthur E., Rice, Kenner C.
Publicado em 2012

“...-compound 1 has been found to have high affinity for the IL-6 receptor and to act as an IL-6 antagonist. A...”
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184

A β-Carboline Alkaloid from the Papua New Guinea Marine Sponge Hyrtios reticulatus

A β-Carboline Alkaloid from the Papua New Guinea Marine Sponge Hyrtios reticulatus

Por Inman, Wayne D., Bray, Walter M., Gassner, Nadine C., Lokey, R. Scott, Tenney, Karen, Shen, Young Yongchun, TenDyke, Karen, Suh, Ted, Crews, Phillip
Publicado em 2010

“...A new 1-imidazoyl-3-carboxy-6-hydroxy-β-carboline alkaloid, named hyrtiocarboline (1), was isolated...”
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185

A step closer toward therapies for p63-related disorders

A step closer toward therapies for p63-related disorders

Por Zhou, Huiqing, Aberdam, Daniel
Publicado em 2013

“... targeting mutant p53 have been tested. One of such low molecular weight compounds is APR246/PRIMA-1(MET...”
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186

Data and models from multi-model inference of non-random mating from an information theoretic approach

Data and models from multi-model inference of non-random mating from an information theoretic approach

Por Carvajal-Rodríguez, Antonio
Publicado no Data Brief (2019)

“...This is a co-submission with Multi-model inference of non-random mating from an information...”
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187

Prevalence of Epidermal Growth Factor Receptor Mutations in Patients with Non-Small Cell Lung Cancer in Turkish Population

Prevalence of Epidermal Growth Factor Receptor Mutations in Patients with Non-Small Cell Lung Cancer in Turkish Population

Por Güler Tezel, Gaye, Şener, Ebru, Aydın, Çisel, Önder, Sevgen
Publicado no Balkan Med J (2017)

“... mutations (38.1.1%, 61/160). We also detected compound mutation patterns in three cases (1.9%). CONCLUSION...”
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188

Systemic Induction of the Small Antibacterial Compound in the Leaf Exudate During Benzothiadiazole-elicited Systemic Acquired Resistance in Pepper

Systemic Induction of the Small Antibacterial Compound in the Leaf Exudate During Benzothiadiazole-elicited Systemic Acquired Resistance in Pepper

Por Lee, Boyoung, Park, Yong-Soon, Yi, Hwe-Su, Ryu, Choong-Min
Publicado em 2013

“... of a chemical trigger, benzothiadiazole (BTH). Elicitation of plant immunity was confirmed...”
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189

Novel small molecule inhibiting CDCP1‐PKCδ pathway reduces tumor metastasis and proliferation

Novel small molecule inhibiting CDCP1‐PKCδ pathway reduces tumor metastasis and proliferation

Por Nakashima, Katsuhiko, Uekita, Takamasa, Yano, Shigenobu, Kikuchi, Jun‐ichi, Nakanishi, Ruri, Sakamoto, Nozomi, Fukumoto, Keisuke, Nomoto, Akihiro, Kawamoto, Keisuke, Shibahara, Takashi, Yamaguchi, Hideki, Sakai, Ryuichi
Publicado no Cancer Sci (2017)

“...CUB domain‐containing protein‐1 (CDCP1) is a trans‐membrane protein predominantly expressed...”
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190

Cerebral Small Vessel Disease Related to a Heterozygous Nonsense Mutation in HTRA1

Cerebral Small Vessel Disease Related to a Heterozygous Nonsense Mutation in HTRA1

Por Ohta, Kentaro, Ozawa, Tetsuo, Fujinaka, Hidehiko, Goto, Kiyoe, Nakajima, Takashi
Publicado no Intern Med (2020)

“...Homozygous or compound heterozygous mutations in the high-temperature requirement A serine protease...”
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191

Impairing Powerhouse in Colon Cancer Cells by Hydrazide–Hydrazone-Based Small Molecule

Impairing Powerhouse in Colon Cancer Cells by Hydrazide–Hydrazone-Based Small Molecule

Por Patil, Sohan, Kuman, Meenu Mahesh, Palvai, Sandeep, Sengupta, Poulomi, Basu, Sudipta
Publicado no ACS Omega (2018)

“...–hydrazone-based small molecules and identified a novel compound that induces mitochondrial outer membrane...”
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192

Histone Deacetylase Inhibitors from Burkholderia Thailandensis

Histone Deacetylase Inhibitors from Burkholderia Thailandensis

Por Klausmeyer, Paul, Shipley, Suzanne, Zuck, Karina M., McCloud, Thomas G.
Publicado em 2011

“... and identification of a new cytotoxic depsipeptide and its dimer. Both compounds potently inhibited the function...”
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193

Small Molecule Anti-Cancer Compounds Selectively Target the Hemopexin Domain of Matrix Metalloproteinase-9 (MMP-9)

Small Molecule Anti-Cancer Compounds Selectively Target the Hemopexin Domain of Matrix Metalloproteinase-9 (MMP-9)

Por Dufour, Antoine, Sampson, Nicole S., Li, Jian, Kuscu, Cem, Rizzo, Robert C., DeLeon, Jennifer L., Zhi, Jizu, Jaber, Nadia, Liu, Eric, Zucker, Stanley, Cao, Jian
Publicado em 2011

“... metastasis. Thus, we have demonstrated for the first time that a novel small molecule interacts specifically...”
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194

Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound

... by an enantiomeric iridium(iii) metal-based compound ...

Por Liu, Li-Juan, Wang, Wanhe, Huang, Shi-Ying, Hong, Yanjun, Li, Guodong, Lin, Sheng, Tian, Jinglin, Cai, Zongwei, Wang, Hui-Min David, Ma, Dik-Lung, Leung, Chung-Hang
Publicado no Chem Sci (2017)

“... the identification of iridium(iii) compounds as inhibitors of the H-Ras/Raf-1 PPI. The lead iridium(iii) compound 1...”
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195

The Ibr‐7 derivative of ibrutinib exhibits enhanced cytotoxicity against non‐small cell lung cancer cells via targeting of mTORC1/S6 signaling

The Ibr‐7 derivative of ibrutinib exhibits enhanced cytotoxicity against non‐small cell lung cancer cells via targeting of mTORC1/S6 signaling

Por Zhang, Bo, Wang, Linling, Zhang, Qi, Yan, Youyou, Jiang, Hong, Hu, Runlei, Zhou, Xinglu, Liu, Xingguo, Feng, Jianguo, Lin, Nengming
Publicado no Mol Oncol (2019)

“...Ibrutinib is a small molecule drug that targets Bruton's tyrosine kinase in B‐cell malignancies...”
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196

Macrophage activation by a substituted pyrimido[5,4-b]indole increases anti-cancer activity

Macrophage activation by a substituted pyrimido[5,4-b]indole increases anti-cancer activity

Por Hardie, Joseph, Mas-Rosario, Javier A., Ha, Siyoung, Rizzo, Erik M., Farkas, Michelle E.
Publicado no Pharmacol Res (2019)

“...Immunotherapy has become a promising new approach for cancer treatment due to the immune system’s...”
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197

Examination of SOD1 aggregation modulators and their effect on SOD1 enzymatic activity as a proxy for potential toxicity

Examination of SOD1 aggregation modulators and their effect on SOD1 enzymatic activity as a proxy for potential toxicity

Por Malik, Ravinder, Corrales, Christian, Linsenmeier, Miriam, Alalami, Huda, Sepanj, Niki, Bitan, Gal
Publicado no FASEB J (2020)

“... including the different phases of fluorescence change and added a parallel screen of SOD1 activity as a...”
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198

Small-molecule inhibitors of Haemophilus influenzae IgA1 protease

Small-molecule inhibitors of Haemophilus influenzae IgA1 protease

Por Shehaj, Livia, Choudary, Santosh K., Makwana, Kamlesh M., Gallo, Mary C., Murphy, Timothy F., Kritzer, Joshua A.
Publicado no ACS Infect Dis (2019)

“... report the discovery of the first small molecule, non-peptidic inhibitors of H. influenzae IgA1 proteases...”
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199

Evaluation of the cytotoxic potential of a new pentacyclic triterpene from Rhododendron arboreum stem bark

Evaluation of the cytotoxic potential of a new pentacyclic triterpene from Rhododendron arboreum stem bark

Por Sajid Ali, Muhammad Nisar, Muhammad Qaisar, Aslam Khan, Abid Ali Khan
Publicado em 2017-01-01

“.... Structure elucidation of new compound was performed through extensive spectroscopy i.e., IR, MS and 1D and 2...”
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200

Influence of Dimethylsulfoxide on RNA Structure and Ligand Binding

Influence of Dimethylsulfoxide on RNA Structure and Ligand Binding

Por Lee, Janghyun, Vogt, Catherine E., McBrairty, Mitchell, Al-Hashimi, Hashim M.
Publicado em 2013

“... that by competing for hydrophobic interactions, DMSO can have a small but significant effect on RNA structure...”
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