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The Ibr‐7 derivative of ibrutinib exhibits enhanced cytotoxicity against non‐small cell lung cancer cells via targeting of mTORC1/S6 signaling

Ibrutinib is a small molecule drug that targets Bruton's tyrosine kinase in B‐cell malignancies and is highly efficient at killing mantle cell lymphoma and chronic lymphocytic leukemia. However, the anti‐cancer activity of ibrutinib against solid tumors, such as non‐small cell lung cancer (NSCL...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Zhang, Bo, Wang, Linling, Zhang, Qi, Yan, Youyou, Jiang, Hong, Hu, Runlei, Zhou, Xinglu, Liu, Xingguo, Feng, Jianguo, Lin, Nengming
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441926/
https://ncbi.nlm.nih.gov/pubmed/30663221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12454
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