Resultados da pesquisa - (( j mental nerve case di ) OR ((( j abducent nerve cyst dis ) OR ( j genes drive system due ))))*

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A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus

Por Valderrama, J. Andrés, Kulkarni, Surashree S., Nizet, Victor, Bier, Ethan
Publicado no Nat Commun (2019)

“...Gene-drive systems in diploid organisms bias the inheritance of one allele over another. CRISPR...”
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The use of driving endonuclease genes to suppress mosquito vectors of malaria in temporally variable environments

Por Ben Lambert, Ace North, Austin Burt, H. Charles J. Godfray
Publicado em 2018-04-01

“...Abstract Background The use of gene drive systems to manipulate populations of malaria vectors...”
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The use of driving endonuclease genes to suppress mosquito vectors of malaria in temporally variable environments

Por Lambert, Ben, North, Ace, Burt, Austin, Godfray, H. Charles J.
Publicado no Malar J (2018)

“...BACKGROUND: The use of gene drive systems to manipulate populations of malaria vectors is currently...”
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Horizontal Transfer, Not Duplication, Drives the Expansion of Protein Families in Prokaryotes

Por Treangen, Todd J., Rocha, Eduardo P. C.
Publicado em 2011

“... possibly due to a higher/longer adaptive role. On the other hand, duplicated genes—paralogs—are expressed...”
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Genetic Systems to Investigate Regulation of Oncogenes and Tumour Suppressor Genes in Drosophila

Por Lee, Jue Er Amanda, Cranna, Nicola J., Chahal, Arjun S., Quinn, Leonie M.
Publicado em 2012

“... organ growth and excessive proliferation, potentially resulting in tissue overgrowth and driving tumour...”
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Targeting of temperate phages drives loss of type I CRISPR-Cas systems

Por Rollie, Clare, Chevallereau, Anne, Watson, Bridget N.J., Chyou, Te-yuan, Fradet, Olivier, McLeod, Isobel, Fineran, Peter C., Brown, Chris M., Gandon, Sylvain, Westra, Edze R.
Publicado no Nature (2020)

“..., our data suggest that CRISPR-Cas immune systems are in this context maladaptive to the host due...”
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Tet1 Isoforms Differentially Regulate Gene Expression, Synaptic Transmission, and Memory in the Mammalian Brain

Por Greer, C.B., Wright, J., Weiss, J.D., Lazarenko, R.M., Moran, S.P., Zhu, J., Chronister, K.S., Jin, A.Y., Kennedy, A.J., Sweatt, J.D., Kaas, G.A.
Publicado no J Neurosci (2021)

“... by contradictory findings, perhaps due in part, to a recent discovery that two isoforms of the Tet1 gene...”
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Combining Gene–Disease Associations with Single-Cell Gene Expression Data Provides Anatomy-Specific Subnetworks in Age-Related Macular Degeneration

Por Luthert, Philip J., Kiel, Christina
Publicado no Netw Syst Med (2020)

“... to be driving the disease pathology. A systems approach to narrow down PPI networks to specific protein drug...”
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Do the same genes underlie parallel phenotypic divergence in different Littorina saxatilis populations?

Por Westram, A M, Galindo, J, Alm Rosenblad, M, Grahame, J W, Panova, M, Butlin, R K
Publicado no Mol Ecol (2014)

“... loci due to recent shared ancestry and gene flow between at least two of the locations in our study...”
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The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae

Por Obbard, Darren J, Callister, Deborah M, Jiggins, Francis M, Soares, Dinesh C, Yan, Guiyun, Little, Tom J
Publicado em 2008

“... by long-term balancing selection, but is instead due to two independent gene conversion events from one...”
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Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

Por Lee, Hyun Jae, Georgiadou, Athina, Walther, Michael, Nwakanma, Davis, Stewart, Lindsay B., Levin, Michael, Otto, Thomas D., Conway, David J., Coin, Lachlan J., Cunnington, Aubrey J.
Publicado no Sci Transl Med (2018)

“...-infected Gambian children to reveal mechanisms driving the systemic pathophysiology of severe malaria...”
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A Sox10(rtTA/+) Mouse Line Allows for Inducible Gene Expression in the Auditory and Balance Organs of the Inner Ear

Por Walters, Bradley J., Zuo, Jian
Publicado no J Assoc Res Otolaryngol (2015)

“...-inducible systems (Tet-On/Off) provide temporal and cell-type specific control of gene expression, offering...”
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Tuning and controlling gene expression noise in synthetic gene networks

Por Murphy, Kevin F., Adams, Rhys M., Wang, Xiao, Balázsi, Gábor, Collins, James J.
Publicado em 2010

“... of applications. In many instances, however, such networks can behave unreliably due to gene expression noise...”
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Medullary 5-HT neurons: Switch from tonic respiratory drive to chemoreception during postnatal development

Por Cerpa, Veronica J., Wu, Yuanming, Bravo, Eduardo, Teran, Frida A., Flynn, Rachel S., Richerson, George B.
Publicado no Neuroscience (2016)

“... in vivo. A defect in the 5-HT system in early postnatal life decreases survival due in part to hypoxia....”
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Secreted Bacterial Effectors and Host-Produced Eiger/TNF Drive Death in a Salmonella-Infected Fruit Fly

Por Brandt, Stephanie M, Dionne, Marc S, Khush, Ranjiv S, Pham, Linh N, Vigdal, Thomas J, Schneider, David S
Publicado em 2004

“...Death by infection is often as much due to the host's reaction as it is to the direct result...”
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Systemic Iron Overload Exacerbates Osteoarthritis in the Strain 13 Guinea Pig

Por Burton, Lindsey H., Radakovich, Lauren B., Marolf, Angela J., Santangelo, Kelly S.
Publicado no Osteoarthritis Cartilage (2020)

“... and histologic scoring systems. Gene analyses revealed that exogenous iron altered the expression of iron...”
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Modeling the mutation and reversal of engineered underdominance gene drives

Por Edgington, Matthew P., Alphey, Luke S.
Publicado no J Theor Biol (2019)

“...A range of gene drive systems have been proposed that are predicted to increase their frequency...”
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Mouse models in the era of large human tumour sequencing studies

Por de Ruiter, J. R., Wessels, L. F. A., Jonkers, J.
Publicado no Open Biol (2018)

“... their cellular processes. A fraction of these mutations drive tumourigenesis by affecting oncogenes or tumour...”
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Experience-dependent Epigenetic Modifications in the CNS

Por Sweatt, J. David
Publicado em 2008

“...This mini-review describes recent discoveries demonstrating that experience can drive...”
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Oxidative stress-based therapeutics in COPD

Por Barnes, Peter J.
Publicado no Redox Biol (2020)

“... and FOXO that regulate multiple antioxidant genes. Increased systemic oxidative stress may exacerbate...”
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