Tet1 Isoforms Differentially Regulate Gene Expression, Synaptic Transmission, and Memory in the Mammalian Brain

The dynamic regulation of DNA methylation in postmitotic neurons is necessary for memory formation and other adaptive behaviors. Ten-eleven translocation 1 (TET1) plays a part in these processes by oxidizing 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), thereby initiating active DNA deme...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Greer, C.B., Wright, J., Weiss, J.D., Lazarenko, R.M., Moran, S.P., Zhu, J., Chronister, K.S., Jin, A.Y., Kennedy, A.J., Sweatt, J.D., Kaas, G.A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2021
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7842754/
https://ncbi.nlm.nih.gov/pubmed/33262245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1821-20.2020
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