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1

CSI: Cancer Signature Investigation: ERBB2 (HER2)-Activating Mutation and Amplification-Positive Breast Carcinoma Mimicking Lung Primary

CSI: Cancer Signature Investigation: ERBB2 (HER2)-Activating Mutation and Amplification-Positive Breast Carcinoma Mimicking Lung Primary

Por Shih, Jennifer, Bashir, Babar, Gustafson, Karen S., Andrake, Mark, Dunbrack, Roland L., Goldstein, Lori J., Boumber, Yanis
Publicado no J Natl Compr Canc Netw (2015)

“... response. This case demonstrates that a unique genetic mutational profile can clarify whether a tumor...”
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2

A Distributed Network for Intensive Longitudinal Monitoring in Metastatic Triple-Negative Breast Cancer

A Distributed Network for Intensive Longitudinal Monitoring in Metastatic Triple-Negative Breast Cancer

Por Blau, C. Anthony, Ramirez, Arturo B., Blau, Sibel, Pritchard, Colin C., Dorschner, Michael O., Schmechel, Stephen C., Martins, Timothy J., Mahen, Elisabeth M., Burton, Kimberly A., Komashko, Vitalina M., Radenbaugh, Amie J., Dougherty, Katy, Thomas, Anju, Miller, Christopher P., Annis, James, Fromm, Jonathan R., Song, Chaozhong, Chang, Elizabeth, Howard, Kellie, Austin, Sharon, Schmidt, Rodney A., Linenberger, Michael L., Becker, Pamela S., Senecal, Francis M., Mecham, Brigham H., Lee, Su-In, Madan, Anup, Ronen, Roy, Dutkowski, Janusz, Heimfeld, Shelly, Wood, Brent L., Stilwell, Jackie L., Kaldjian, Eric P., Haussler, David, Zhu, Jingchun
Publicado no J Natl Compr Canc Netw (2016)

“... patient with cancer can generate high-resolution views of the natural history of cancer and suggest new...”
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3

Existence of a nonarithmetic lattice in SU(2,1)

Existence of a nonarithmetic lattice in SU(2,1)

Por Mostow, G. D.
Publicado em 1978

“... with SU(2,1) of a group Γ generated by three complex reflections of order 5. The quotient SU(2,1)/Γ(1...”
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4

Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila.

Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila.

Por Lewis, E B, Knafels, J D, Mathog, D R, Celniker, S E
Publicado em 1995

“... at more than five sites in the sequence, when < 0.5 case is expected. Expected values are based on a third...”
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5

Probing the structure of Nun transcription arrest factor bound to RNA polymerase

Probing the structure of Nun transcription arrest factor bound to RNA polymerase

Por Mustaev, Arkady, Vitiello, Christal L., Gottesman, Max E.
Publicado no Proc Natl Acad Sci U S A (2016)

“... complex (TEC). Both the 5′ and the 3′ ends of the RNA cross-link Nun, implying that Nun contacts RNA...”
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6

Multiple enhancer-like sequences in the HLA-B7 gene.

Multiple enhancer-like sequences in the HLA-B7 gene.

Por Ganguly, S, Vasavada, H A, Weissman, S M
Publicado em 1989

“... 3 and 5 as well as 5' to the transcription initiation site. RNase protection experiments corroborate...”
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7

A "bulged" double helix in a RNA-protein contact site.

A "bulged" double helix in a RNA-protein contact site.

Por Peattie, D A, Douthwaite, S, Garrett, R A, Noller, H F
Publicado em 1981

“... as detected by dimethyl sulfate alkylation and RNase A digestion of the 5S-L18 complex. Most of the affected...”
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8

Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent.

Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent.

Por Fritzberg, A R, Abrams, P G, Beaumier, P L, Kasina, S, Morgan, A C, Rao, T N, Reno, J M, Sanderson, J A, Srinivasan, A, Wilbur, D S
Publicado em 1988

“...) forms highly stable, well-defined tetradentate complexes with Tc(V). Antibodies and their fragments have...”
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9

Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle

Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle

Por Brooks, George A., Dubouchaud, Hervé, Brown, Marcia, Sicurello, James P., Butz, C. Eric
Publicado em 1999

“... incubated with lactate, pyruvate, glutamate, and succinate. As well, α-cyano-4-hydroxycinnamate (CINN), a...”
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10

The Bovine Papillomavirus E5 Protein Requires a Juxtamembrane Negative Charge for Activation of the Platelet-Derived Growth Factor β Receptor and Transformation of C127 Cells

The Bovine Papillomavirus E5 Protein Requires a Juxtamembrane Negative Charge for Activation...

Por Klein, Ophir, Kegler-Ebo, Deena, Su, Jennifer, Smith, Steven, DiMaio, Daniel
Publicado em 1999

“... that is the smallest known transforming protein. The E5 protein transforms cultured fibroblasts by forming a stable...”
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11

A possible evolutionary origin for the Mn(4) cluster of the photosynthetic water oxidation complex from natural MnO(2) precipitates in the early ocean

A possible evolutionary origin for the Mn(4) cluster of the photosynthetic water oxidation complex from natural MnO(2) precipitates in the early ocean

Por Sauer, Kenneth, Yachandra, Vittal K.
Publicado em 2002

“... in higher plants and algae, as well as in cyanobacteria of more ancient lineage, dating back more than 2.5...”
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12

The anomalous behavior of the density of water in the range 30 K < T < 373 K

The anomalous behavior of the density of water in the range 30 K < T < 373 K

Por Mallamace, Francesco, Branca, Caterina, Broccio, Matteo, Corsaro, Carmelo, Mou, Chung-Yuan, Chen, Sow-Hsin
Publicado em 2007

“... of T. We observe in ρ(T) a complex thermal behavior characterized not only by the well known maximum...”
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13

SAGA complex mediates the transcriptional up-regulation of antiviral RNA silencing

SAGA complex mediates the transcriptional up-regulation of antiviral RNA silencing

Por Andika, Ida Bagus, Jamal, Atif, Kondo, Hideki, Suzuki, Nobuhiro
Publicado no Proc Natl Acad Sci U S A (2017)

“...) complex, a well-known transcriptional coactivator. Knockout of other SAGA components showed...”
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14

Initial formation of an indigenous crop complex in eastern North America at 3800 B.P

Initial formation of an indigenous crop complex in eastern North America at 3800 B.P

Por Smith, Bruce D., Yarnell, Richard A.
Publicado em 2009

“... 5 domesticated seed-bearing plants formed a coherent complex in the river valley corridors of ENA...”
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15

Structure of the ternary complex of human 17β-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP(+)

Structure of the ternary complex of human 17β-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP(+)

Por Sawicki, Mark W., Erman, Mary, Puranen, Terhi, Vihko, Pirkko, Ghosh, Debashis
Publicado em 1999

“... of the ternary complex of 17β-HSD1 with the cofactor NADP(+) and 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin...”
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16

Crystal structure of the BTB domain from PLZF

Crystal structure of the BTB domain from PLZF

Por Ahmad, K. Farid, Engel, Christian K., Privé, Gilbert G.
Publicado em 1998

“... interaction motif found at the N terminus of 5–10% of C(2)H(2)-type zinc-finger transcription factors, as well...”
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17

Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons.

Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons.

Por Kaltschmidt, C, Kaltschmidt, B, Baeuerle, P A
Publicado em 1995

“...L-Glutamate is the most common excitatory neurotransmitter in the brain and plays a crucial role...”
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18

Crystal structure of a core spliceosomal protein interface

Crystal structure of a core spliceosomal protein interface

Por Schellenberg, Matthew J., Edwards, Ross A., Ritchie, Dustin B., Kent, Oliver A., Golas, Monika M., Stark, Holger, Lührmann, Reinhard, Glover, J. N. Mark, MacMillan, Andrew M.
Publicado em 2006

“... by the spliceosome, a complex assembly containing five small nuclear ribonucleoprotein (snRNP) particles. Human p14...”
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19

Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor

Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor

Por Hackeng, Tilman M., Seré, Kristin M., Tans, Guido, Rosing, Jan
Publicado em 2006

“... is well known as the cofactor of activated protein C, specifically inhibits TF activity by promoting...”
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20

Structure-function analysis of integrase interactor 1/hSNF5L1 reveals differential properties of two repeat motifs present in the highly conserved region

Structure-function analysis of integrase interactor 1/hSNF5L1 reveals differential properties of two repeat motifs present in the highly conserved region

Por Morozov, Alexei, Yung, Eric, Kalpana, Ganjam V.
Publicado em 1998

“... mammalian SWI/SNF complex that can remodel chromatin. Little is known about the function of Ini1...”
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