Structure of the ternary complex of human 17β-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP(+)

Excess 17β-estradiol (E(2)), the most potent of human estrogens, is known to act as a stimulus for the growth of breast tumors. Human estrogenic 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), which catalyzes the reduction of inactive estrone (E(1)) to the active 17β-estradiol in breast tissues,...

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Hlavní autoři: Sawicki, Mark W., Erman, Mary, Puranen, Terhi, Vihko, Pirkko, Ghosh, Debashis
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1999
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC15312/
https://ncbi.nlm.nih.gov/pubmed/9927655
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