Resultados da pesquisa - (( j l comer a newly ) OR ((( a natl complex can now ) OR ( l oil company care now ))))

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1

Synthesis
of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled
by Stereospecific, Directed C(sp(3))–H Arylation

Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp(3))–H Arylation

Por Maetani, Micah, Zoller, Jochen, Melillo, Bruno, Verho, Oscar, Kato, Nobutaka, Pu, Jun, Comer, Eamon, Schreiber, Stuart L.
Publicado no J Am Chem Soc (2017)

“... three stages of the parasite’s life cycle, but a lengthy synthetic route to these compounds may affect...”
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2

Chapare Virus, a Newly Discovered Arenavirus Isolated from a Fatal Hemorrhagic Fever Case in Bolivia

Chapare Virus, a Newly Discovered Arenavirus Isolated from a Fatal Hemorrhagic Fever Case in Bolivia

Por Delgado, Simon, Erickson, Bobbie R., Agudo, Roberto, Blair, Patrick J., Vallejo, Efrain, Albariño, César G., Vargas, Jorge, Comer, James A., Rollin, Pierre E., Ksiazek, Thomas G., Olson, James G., Nichol, Stuart T.
Publicado em 2008

“... of the complete virus S and L RNA segment sequences identified the virus as a member of the New World Clade B...”
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3

Growth of complex systems can be related to the properties of their underlying determinants

Growth of complex systems can be related to the properties of their underlying determinants

Por Savageau, Michael A.
Publicado em 1979

“.... Such laws have been noted in a wide variety of fields for many years. Until now these laws have never been...”
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4

Small nuclear RNAs from Saccharomyces cerevisiae: unexpected diversity in abundance, size, and molecular complexity.

Small nuclear RNAs from Saccharomyces cerevisiae: unexpected diversity in abundance, size, and molecular complexity.

Por Riedel, N, Wise, J A, Swerdlow, H, Mak, A, Guthrie, C
Publicado em 1986

“..., that the length of the capped RNAs can exceed 1000 nucleotides, and that the relative abundance of a subset...”
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5

Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of major histocompatibility complex class I antigens.

Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of major histocompatibility complex class I antigens.

Por Pääbo, S, Nilsson, T, Peterson, P A
Publicado em 1986

“... products in the context of class I major histocompatibility complex (MHC) antigens. To evade such immune...”
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6

Contrasting complexity of two rust resistance loci in flax.

Contrasting complexity of two rust resistance loci in flax.

Por Ellis, J G, Lawrence, G J, Finnegan, E J, Anderson, P A
Publicado em 1995

“... and molecular data indicate that the L locus is simple and contains a single gene with 13 alleles and that the M...”
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7

Host cell-mediated selection of a mutant influenza A virus that has lost a complex oligosaccharide from the tip of the hemagglutinin.

Host cell-mediated selection of a mutant influenza A virus that has lost a complex oligosaccharide from the tip of the hemagglutinin.

Por Deom, C M, Caton, A J, Schulze, I T
Publicado em 1986

“...During serial passage in Madin-Darby bovine kidney (MDBK) cells, a substrain of influenza virus A...”
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8

Role of interleukin 1 in the activation of T lymphocytes.

Role of interleukin 1 in the activation of T lymphocytes.

Por Lichtman, A H, Chin, J, Schmidt, J A, Abbas, A K
Publicado em 1988

“... and Th2 cells, respectively. We now show that IL-1 functions as a costimulator for the proliferation...”
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9

Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein

Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein

Por Lyapina, Svetlana A., Correll, Craig C., Kipreos, Edward T., Deshaies, Raymond J.
Publicado em 1998

“... of an effort to identify components and substrates of a putative human SCF complex, we isolated hSKP1 in a two...”
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10

E2F-6, a member of the E2F family that can behave as a transcriptional repressor

E2F-6, a member of the E2F family that can behave as a transcriptional repressor

Por Trimarchi, Jeffrey M., Fairchild, Brian, Verona, Raluca, Moberg, Ken, Andon, Nancy, Lees, Jacqueline A.
Publicado em 1998

“... of genes that direct the process of cell division. All previously identified E2F proteins can act in a...”
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11

Use of photoactivatable peptide substrates of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p) to characterize a myristoyl-CoA-Nmt1p-peptide ternary complex and to provide evidence for an ordered reaction mechanism.

Use of photoactivatable peptide substrates of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p) to characterize a myristoyl-CoA-Nmt1p-peptide ternary complex and to provide evidence...

Por Rudnick, D A, Rocque, W J, McWherter, C A, Toth, M V, Jackson-Machelski, E, Gordon, J I
Publicado em 1993

“... at position 2 or the epsilon-amino group of a lysine residue located at position 8. The photopeptides can...”
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12

Monoclonal radioimmunoassays for hepatitis B surface antigen: demonstration of hepatitis B virus DNA or related sequences in serum and viral epitopes in immune complexes.

Monoclonal radioimmunoassays for hepatitis B surface antigen: demonstration of hepatitis B virus DNA or related sequences in serum and viral epitopes in immune complexes.

Por Shafritz, D A, Lieberman, H M, Isselbacher, K J, Wands, J R
Publicado em 1982

“... for the detection of HBsAg-associated determinants in serum. We now report that selected serum samples demonstrating...”
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13

Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena.

Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena.

Por Pyle, A M, McSwiggen, J A, Cech, T R
Publicado em 1990

“.... We now show that equilibrium dissociation constants for complexes between the Tetrahymena ribozyme...”
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14

Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons.

Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons.

Por Gurney, A M, Tsien, R Y, Lester, H A
Publicado em 1987

“...Although Ca2+ is a well-established intracellular messenger, there are many questions concerning...”
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15

Lyme disease: a growing threat to urban populations.

Lyme disease: a growing threat to urban populations.

Por Steere, A C
Publicado em 1994

“... burgdorferi, is transmitted in North America, Europe, and Asia by ticks of the Ixodes ricinus complex...”
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16

Induction of high titers of anti-IgE by immunization of inbred mice with syngeneic IgE.

Induction of high titers of anti-IgE by immunization of inbred mice with syngeneic IgE.

Por Haba, S, Nisonoff, A
Publicado em 1987

“... by immunization of A/J mice with syngeneic monoclonal IgE conjugated to keyhole limpet hemocyanin. As much as 3 mg...”
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17

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.

Por Laurent, A G, Krust, B, Galabru, J, Svab, J, Hovanessian, A G
Publicado em 1985

“... interferon-treated human Daudi cells, we can now describe the preparation of murine monoclonal antibodies...”
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18

Expression in L cells of transfected class I genes from the mouse major histocompatibility complex.

Expression in L cells of transfected class I genes from the mouse major histocompatibility complex.

Por Schepart, B S, Woodward, J G, Palmer, M J, Macchi, M J, Basta, P, McLaughlin-Taylor, E, Frelinger, J A
Publicado em 1985

“... the lambda 3a clone was transfected into mouse L cells, a new product was expressed. Cells expressing...”
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19

Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.

Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.

Por Martin, L H, Calabi, F, Lefebvre, F A, Bilsland, C A, Milstein, C
Publicado em 1987

“...The CD1 human antigens are a family of at least three components, CD1a, CD1b, and CD1c...”
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20

The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.

The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.

Por Sica, A, Tan, T H, Rice, N, Kretzschmar, M, Ghosh, P, Young, H A
Publicado em 1992

“..., we have now identified two protein-binding regions in this intronic enhancer element. One...”
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