Resultados da pesquisa - (( j d comida can net ) OR ( l r amp camp new ))

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Dual-Mode FRET and BRET Sensors for Detecting cAMP Dynamics

Por French, Alexander R., Tesmer, Alexander L., Tantama, Mathew
Publicado no ACS Omega (2019)

“... our ability to monitor physiology in real time, but the separate development of new sensors for each...”
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Loss of growth polarity and mislocalization of septa in a Neurospora mutant altered in the regulatory subunit of cAMP-dependent protein kinase.

Por Bruno, K S, Aramayo, R, Minke, P F, Metzenberg, R L, Plamann, M
Publicado em 1996

“... regulatory subunit of cAMP-dependent protein kinase (PKA). Unexpectedly, the mcb mutant still formed septa...”
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cAMP and EPAC Signaling Functionally Replace OCT4 During Induced Pluripotent Stem Cell Reprogramming

Por Fritz, Ashley L, Adil, Maroof M, Mao, Sunnie R, Schaffer, David V
Publicado no Mol Ther (2015)

“... reprogramming, we initially found that several pathways—such as Notch, Smoothened, and cyclic AMP (cAMP...”
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Ex vivo cytotoxic drug evaluation by DiSC assay to expedite identification of clinical targets: results with 8-chloro-cAMP.

Por Bosanquet, A. G., Burlton, A. R., Bell, P. B., Harris, A. L.
Publicado em 1997

“... of 8-Cl-cAMP, point to several new phase I, II and III trial possibilities and provide a rationale...”
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Endothelial cAMP deactivates ischemia-reperfusion-induced microvascular hyperpermeability via Rap1-mediated mechanisms

Por Korayem, Adam H., Mujica, Patricio E., Aramoto, Haruo, Durán, Ricardo G., Nepali, Prerna R., Kim, David D., Harris, Andrew L., Sánchez, Fabiola A., Durán, Walter N.
Publicado no Am J Physiol Heart Circ Physiol (2017)

“... endothelial cells (HMVECs), that hyperpermeability can be deactivated by increasing cAMP levels through...”
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Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons

Por Cheng, Qing, Yakel, Jerrel L.
Publicado no Neuropharmacology (2015)

“...-dependent manner. Here, we investigated any connection between the activation of the α7 nAChR and cAMP...”
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Lack of cAMP-response Element-binding Protein 1 in the Hypothalamus Causes Obesity

Por Chiappini, Franck, Cunha, Lucas L., Harris, Jamie C., Hollenberg, Anthony N.
Publicado em 2011

“... disruption causes severe obesity in mice and humans. cAMP-response element-binding protein 1 (CREB1) has been...”
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Signal transduction of stress via ceramide.

Por Mathias, S, Peña, L A, Kolesnick, R N
Publicado em 1998

“... analogous to conventional systems such as the cAMP and phosphoinositide pathways. Ceramide, which serves...”
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A Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation Requiring cAMP in the Medial Perforant Pathway of Rat Hippocampal Slices

Por Nguyen, Peter V., Kandel, Eric R.
Publicado no J Neurosci (1996)

“..., and was selectively blocked by inhibitors of cAMP-dependent protein kinase (PKA). Forskolin, an adenylate cyclase...”
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Thyroid and Bone: Macrophage-Derived TSH-β Splice Variant Increases Murine Osteoblastogenesis

Por Baliram, R., Chow, A., Huber, A. K., Collier, L., Ali, M. R., Morshed, S. A., Latif, R., Teixeira, A., Merad, M., Liu, L., Sun, L., Blair, H. C., Zaidi, M., Davies, T. F.
Publicado em 2013

“..., were able to generate the production of intracellular cAMP; a phenomenon not seen in control CHO cells...”
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A Gα(s) DREADD Mouse for Selective Modulation of cAMP Production in Striatopallidal Neurons

Por Farrell, Martilias S, Pei, Ying, Wan, Yehong, Yadav, Prem N, Daigle, Tanya L, Urban, Daniel J, Lee, Hyeong-Min, Sciaky, Noah, Simmons, Arkeen, Nonneman, Randal J, Huang, Xi-Ping, Hufeisen, Sandy J, Guettier, Jean-Marc, Moy, Sheryl S, Wess, Jürgen, Caron, Marc G, Calakos, Nicole, Roth, Bryan L
Publicado em 2013

“...). We first show that in vitro, rM3Ds can couple to Gα(olf) and induce cAMP accumulation in cultured...”
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Laminin enhances β(2)-adrenergic receptor stimulation of L-type Ca(2+) current via cytosolic phospholipase A(2) signalling in cat atrial myocytes

Por Pabbidi, M R, Ji, X, Samarel, A M, Lipsius, S L
Publicado em 2009

“... inhibited zint-β(2)-AR stimulation of I(Ca,L) in +LMN myocytes and −LMN myocytes in which cAMP/PKA...”
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Steady-State Modulation of Voltage-Gated K(+) Channels in Rat Arterial Smooth Muscle by Cyclic AMP-Dependent Protein Kinase and Protein Phosphatase 2B

Por Brignell, Jennifer L., Perry, Matthew D., Nelson, Carl P., Willets, Jonathon M., Challiss, R. A. John, Davies, Noel W.
Publicado no PLoS One (2015)

“...-cAMP failed to enhance K(v) currents. We also show that this modulation of K(v) by PKA can be reversed...”
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Activated cAMP Response Element Binding Protein Is Overexpressed in Human Mesotheliomas and Inhibits Apoptosis

Por Shukla, Arti, Bosenberg, Marcus W., MacPherson, Maximilian B., Butnor, Kelly J., Heintz, Nicholas H., Pass, Harvey I., Carbone, Michele, Testa, Joseph R., Mossman, Brooke T.
Publicado em 2009

“.../TERT-1) and isolated human pleural mesothelial cells showed rapid and protracted asbestos-induced cAMP...”
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Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling

Por Suryavanshi, Santosh V., Jadhav, Shweta M., Anderson, Kody L., Katsonis, Panagiotis, Lichtarge, Olivier, McConnell, Bradley K.
Publicado no Am J Physiol Heart Circ Physiol (2018)

“... AKAP (mAKAP) partly regulates cardiac cAMP/PKA signaling by binding to PKA and phosphodiesterase 4D3...”
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The Structural Basis for Phospholamban Inhibition of the Calcium Pump in Sarcoplasmic Reticulum

Por Akin, Brandy L., Hurley, Thomas D., Chen, Zhenhui, Jones, Larry R.
Publicado em 2013

“... contractile strength. cAMP-dependent phosphorylation of PLB reverses Ca(2+)-ATPase inhibition with powerful...”
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p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway

Por Sachs, Benjamin D., Baillie, George S., McCall, Julianne R., Passino, Melissa A., Schachtrup, Christian, Wallace, Derek A., Dunlop, Allan J., MacKenzie, Kirsty F., Klussmann, Enno, Lynch, Martin J., Sikorski, Shoana L., Nuriel, Tal, Tsigelny, Igor, Zhang, Jin, Houslay, Miles D., Chao, Moses V., Akassoglou, Katerina
Publicado em 2007

“... mechanism in which phosphodiesterase PDE4A4/5 interacts with p75(NTR) to enhance cAMP degradation. The p75...”
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A novel natural product compound enhances cAMP-regulated chloride conductance of cells expressing CFTR[delta]F508.

Por deCarvalho, Ana C. V., Ndi, Chi P., Tsopmo, Apollinaire, Tane, Pierre, Ayafor, Johnson, Connolly, Joseph D., Teem, John L.
Publicado em 2002

“... is warranted as a means for producing new therapies for CF. MATERIALS AND METHODS: The yeast two-hybrid assay...”
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Leydig Cell Aging and Hypogonadism

Por Beattie, M.C., Adekola, L., Papadopoulos, V., Chen, H., Zirkin, B.R.
Publicado no Exp Gerontol (2015)

“...)-stimulated cAMP production, the cholesterol transport proteins steroidogenic acute regulatory (STAR) protein...”
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cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity

Por Tse, Chung-Ming, Yin, Jianyi, Singh, Varsha, Sarker, Rafiquel, Lin, Ruxian, Verkman, Alan S., Turner, Jerrold R., Donowitz, Mark
Publicado no Cell Mol Gastroenterol Hepatol (2019)

“..., or does not affect its activity. METHODS: This study re-evaluated cAMP regulation of DRA using new tools...”
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