A Gα(s) DREADD Mouse for Selective Modulation of cAMP Production in Striatopallidal Neurons

Here, we describe a newly generated transgenic mouse in which the Gs DREADD (rM3Ds), an engineered G protein-coupled receptor, is selectively expressed in striatopallidal medium spiny neurons (MSNs). We first show that in vitro, rM3Ds can couple to Gα(olf) and induce cAMP accumulation in cultured ne...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Farrell, Martilias S, Pei, Ying, Wan, Yehong, Yadav, Prem N, Daigle, Tanya L, Urban, Daniel J, Lee, Hyeong-Min, Sciaky, Noah, Simmons, Arkeen, Nonneman, Randal J, Huang, Xi-Ping, Hufeisen, Sandy J, Guettier, Jean-Marc, Moy, Sheryl S, Wess, Jürgen, Caron, Marc G, Calakos, Nicole, Roth, Bryan L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671990/
https://ncbi.nlm.nih.gov/pubmed/23303063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.251
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados