A Model-Informed Drug Development (MIDD) Approach for a Low Dose of Empagliflozin in Patients with Type 1 Diabetes

Por Johnston, Curtis K., Eudy-Byrne, Rena J., Elmokadem, Ahmed, Nock, Valerie, Marquard, Jan, Soleymanlou, Nima, Riggs, Matthew M., Liesenfeld, Karl-Heinz
Publicado no Pharmaceutics (2021)

Choice of Starting Dose for Biopharmaceuticals in First-in-Human Phase I Cancer Clinical Trials

Por Hansen, Aaron R., Cook, Natalie, Ricci, M. Stacey, Razak, Albiruni, Le Tourneau, Christophe, McKeever, Kathleen, Roskos, Lorin, Dixit, Rakesh, Siu, Lillian L., Hinrichs, Mary Jane
Publicado no Oncologist (2015)

Pharmacokinetics and Drug Dosing in Obese Children

Por Kendrick, Jennifer G., Carr, Roxane R., Ensom, Mary H.H.
Publicado em 2010

A Phase I Dose‐Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors

Por Leong, Stephen, Moss, Rebecca A., Bowles, Daniel W., Ware, Joseph A., Zhou, Jing, Spoerke, Jill M., Lackner, Mark R., Shankar, Geetha, Schutzman, Jennifer L., van der Noll, Ruud, Voest, Emile E., Schellens, Jan H.M.
Publicado no Oncologist (2017)

Glucagon‐like peptide‐1 receptor agonists for type 2 diabetes: A rational drug development

Por Ahrén, Bo
Publicado no J Diabetes Investig (2018)

Short Communication: A Repeated Simian Human Immunodeficiency Virus Reverse Transcriptase/Herpes Simplex Virus Type 2 Cochallenge Macaque Model for the Evaluation of Microbicides

Por Kenney, Jessica, Derby, Nina, Aravantinou, Meropi, Kleinbeck, Kyle, Frank, Ines, Gettie, Agegnehu, Grasperge, Brooke, Blanchard, James, Piatak, Michael, Lifson, Jeffrey D., Zydowsky, Thomas M., Robbiani, Melissa
Publicado em 2014

Development of a mobile application for vancomycin dosing calculation: A useful tool for the rational use of antimicrobials

Por Tácio de Mendonça Lima, Millena Padela da Silva, Luan Donato Silva Luz, Thais Cristina Amorim Estevão Soares, Etielle Silvestre Dantas, Gabriela Felix Teixeira, Rafael Henrique de Souza Costa, Sérgio Henrique Monte Santo Andrade
Publicado em 2022-03-01

Clinical development of antiepileptic drugs for children

Por Garofalo, Elizabeth
Publicado no Neurotherapeutics (2007)

Oxazolone-Induced Delayed Type Hypersensitivity Reaction in the Adult Yucatan Pigs. A Useful Model for Drug Development and Validation

Por Nuhaily, Samer, Damaj, Bassam B., Maghazachi, Azzam A.
Publicado em 2009

Effect of Study Design on Sample Size in Studies Intended to Evaluate Bioequivalence of Inhaled Short‐Acting β‐Agonist Formulations

Por Zeng, Yaohui, Singh, Sachinkumar, Wang, Kai, Ahrens, Richard C.
Publicado no J Clin Pharmacol (2017)

Insulin Glargine Combined with Oral Antidiabetic Drugs for Asians with Type 2 Diabetes Mellitus: A...

Por Gu, Tianwei, Hong, Ting, Zhang, Pengzi, Tang, Sunyinyan, Bi, Yan, Lu, Hai, Men, Lichuang, Ma, Dongwei, Zhu, Dalong
Publicado no Diabetes Ther (2018)

Improving Conventional or Low Dose Metronomic Chemotherapy with Targeted Antiangiogenic Drugs

Por Kerbel, Robert S.
Publicado em 2007

Dose‐Finding Studies Among Orphan Drugs Approved in the EU: A Retrospective Analysis

Por Schuller, Yvonne, Gispen‐de Wied, Christine, Hollak, Carla E. M., Leufkens, Hubertus G. M., Stoyanova‐Beninska, Violeta
Publicado no J Clin Pharmacol (2018)

Development of an Optimized Dose for Coformulation of Zidovudine with Drugs That Select for the K65...

Por Hurwitz, Selwyn J., Asif, Ghazia, Kivel, Nancy M., Schinazi, Raymond F.
Publicado em 2008

Impact of dextrose dose on hypoglycemia development following treatment of hyperkalemia

Por Farina, Nicholas, Anderson, Christopher
Publicado no Ther Adv Drug Saf (2018)

Lights and Shadows in Immuno-Oncology Drug Development

Por Bergamino Sirvén, Milana, Pernas, Sonia, Cheang, Maggie C. U.
Publicado no Cancers (Basel) (2021)

Accelerating Drug Development Using Biomarkers: A Case Study with Sitagliptin, A Novel DPP4 Inhibitor for Type 2 Diabetes

Por Krishna, Rajesh, Herman, Gary, Wagner, John A.
Publicado em 2008

Analysis of Drug Development Paradigms for Immune Checkpoint inhibitors

Por Jardim, Denis L., de Melo Gagliato, Débora, Giles, Francis J., Kurzrock, Razelle
Publicado no Clin Cancer Res (2017)

Development of drug resistance in a murine mammary tumour.

Por McMillan, T. J., Stephens, T. C., Steel, G. G.
Publicado em 1985

Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia

Por Hovhannisyan, Vladimir, Siposova, Katarina, Musatov, Andrey, Chen, Shean-Jen
Publicado no Sci Rep (2021)