Resultados da pesquisa - ((((drug dosev) OR (drug doseal))) OR (drug dose)) devel ther*

Pesquisas alternativas:
dosev » doses (Expandir a Pesquisa), dosed (Expandir a Pesquisa), dosen (Expandir a Pesquisa), dosv (Expandir a Pesquisa)
doseal » dosear (Expandir a Pesquisa), doseas (Expandir a Pesquisa), coseal (Expandir a Pesquisa), dosal (Expandir a Pesquisa)
dose » dos (Expandir a Pesquisa)
devel » level (Expandir a Pesquisa), devem (Expandir a Pesquisa)
ther* » them* (Expandir a Pesquisa)

101

Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial

Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during...

Por Shami, Shoaleh, Nasseri, Karim, Shirmohammadi, Mousa, Sarshivi, Farzad, Ghadami, Negin, Ghaderi, Ebrahim, Pouladi, Mokhtar, Barzanji, Arvin
Publicado no Drug Des Devel Ther (2016)

“... of two different doses of intrathecal pethidine on the incidence and intensity of shivering and other...”
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102

Effect of preoperative loading dose ticagrelor and clopidogrel on no-reflow phenomenon during intervention in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis

Effect of preoperative loading dose ticagrelor and clopidogrel on no-reflow phenomenon during...

Por Dai, Weiran, Ye, Ziliang, Li, Lang, Su, Qiang
Publicado no Drug Des Devel Ther (2018)

“... in platelet inhibition. However, this conclusion remains controversial. Therefore, we performed this meta...”
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103

Randomized, open-label, blinded-endpoint, crossover, single-dose study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure

Randomized, open-label, blinded-endpoint, crossover, single-dose study to compare...

Por Ballester, Maria Rosa, Roig, Eulàlia, Gich, Ignasi, Puntes, Montse, Delgadillo, Joaquín, Santos, Benjamín, Antonijoan, Rosa Maria
Publicado no Drug Des Devel Ther (2015)

“... single-dose administration. Moreover, the pharmacokinetics of torasemide-PR, furosemide-IR...”
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104

Ambulatory blood pressure parameters after canrenone addition to existing treatment regimens with maximum tolerated dose of angiotensin-converting enzyme inhibitors/angiotensin II type 1 receptor blockers plus hydrochlorothiazide in uncontrolled hypertensive patients

Ambulatory blood pressure parameters after canrenone addition to existing treatment regimens with maximum tolerated dose of angiotensin-converting enzyme inhibitors/angiotensin II type 1 receptor blockers...

Por Guasti, Luigina, Gaudio, Giovanni, Lupi, Alessandro, D’Avino, Marinella, Sala, Carla, Mugellini, Amedeo, Vulpis, Vito, Felis, Salvatore, Sarzani, Riccardo, Vanasia, Massimo, Maffioli, Pamela, Derosa, Giuseppe
Publicado no Drug Des Devel Ther (2017)

“... treated with the highest tolerated dose of angiotensin-converting enzyme (ACE) inhibitors or angiotensin...”
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105

Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions?

Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions?

Por Kim, Choon Ok, Oh, Eun Sil, Kim, Hohyun, Park, Min Soo
Publicado no Drug Des Devel Ther (2017)

“.... Thus, these patients are likely to take glimepiride and rosuvastatin concomitantly. Therefore...”
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106

N-(3-hydroxymethyl-β-carboline-1-yl-ethyl- 2-yl)-l-Phe: development toward a nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation

N-(3-hydroxymethyl-β-carboline-1-yl-ethyl- 2-yl)-l-Phe: development toward a nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation

Por Wu, Jianhui, Zhao, Ming, Wang, Yuji, Wang, Yaonan, Zhu, Haimei, Zhao, Shurui, Gui, Lin, Zhang, Xiaoyi, Peng, Shiqi
Publicado no Drug Des Devel Ther (2017)

“...-selectin is a common target for antithrombotic, anti-inflammatory and antitumor drugs, the aim...”
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107

Pharmacokinetics and tolerability of MB12066, a beta-lapachone derivative targeting NAD(P)H: quinone oxidoreductase 1: two independent, double-blind, placebo-controlled, combined single and multiple ascending dose first-in-human clinical trials

Pharmacokinetics and tolerability of MB12066, a beta-lapachone derivative targeting NAD(P)H: quinone oxidoreductase 1: two independent, double-blind, placebo-controlled, combined single and multiple ascending dose first-in-human clinical trials

Por Kim, Seokuee, Lee, SeungHwan, Cho, Joo-Youn, Yoon, Seo Hyun, Jang, In-Jin, Yu, Kyung-Sang
Publicado no Drug Des Devel Ther (2017)

“... the oral administration of single and multiple doses to healthy volunteers. The study comprised 2...”
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108

Efficacy and safety of two fixed-dose combinations of S-amlodipine and telmisartan (CKD-828) versus S-amlodipine monotherapy in patients with hypertension inadequately controlled using S-amlodipine monotherapy: an 8-week, multicenter, randomized, double-blind, Phase III clinical study

Efficacy and safety of two fixed-dose combinations of S-amlodipine and telmisartan (CKD-828) versus...

Por Ihm, Sang-Hyun, Jeon, Hui-Kyung, Cha, Tae-Joon, Hong, Taek-Jong, Kim, Sang-Hyun, Lee, Nae-Hee, Yoon, Jung Han, Yoon, Namsik, Hwang, Kyung-Kuk, Jo, Sang-Ho, Youn, Ho-Joong
Publicado no Drug Des Devel Ther (2016)

“...PURPOSE: To evaluate the blood pressure (BP) lowering efficacy and safety of CKD-828, a fixed-dose...”
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109

5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors

5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors

Por Gan, Taiping, Wang, Yuji, Zhao, Ming, Wu, Jianhui, Yang, Jian, Peng, Shiqi
Publicado no Drug Des Devel Ther (2016)

“... dose dependently inhibited the metastasis of LLC (Lewis Lung Carcinoma) toward lung. In vivo, 2 µmol/kg...”
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110

The therapeutic efficacy of propranolol in children with recurrent primary epistaxis

The therapeutic efficacy of propranolol in children with recurrent primary epistaxis

Por Bjelakovic, Bojko, Bojanovic, Mila, Lukic, Stevo, Saranac, Ljiljana, Vukomanovic, Vladislav, Prijic, Sergej, Zivkovic, Nikola, Randjelovic, Dusica
Publicado em 2013

“... of propranolol was noted in all seven children when given a dose of 1.5–2 mg/kg/day (divided into three doses...”
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111

Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers

Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers

Por Cossu, Maria Vittoria, Cattaneo, Dario, Fucile, Serena, Pellegrino, Paolo, Baldelli, Sara, Cozzi, Valeria, Capetti, Amedeo, Clementi, Emilio
Publicado em 2014

“... and to optimize the dosing of the combination of the drugs isosorbide dinitrate, a nitric oxide donor...”
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112

Modifying tetramethyl–nitrophenyl–imidazoline with amino acids: design, synthesis, and 3D-QSAR for improving inflammatory pain therapy

Modifying tetramethyl–nitrophenyl–imidazoline with amino acids: design, synthesis, and 3D-QSAR for improving inflammatory pain therapy

Por Jiang, Xueyun, Wang, Yuji, Zhu, Haimei, Wang, Yaonan, Zhao, Ming, Zhao, Shurui, Wu, Jianhui, Li, Shan, Peng, Shiqi
Publicado no Drug Des Devel Ther (2015)

“... excellent oral anti-inflammation and analgesic activity. The dose-dependent assay of their representative 6f...”
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113

The role of concomitant methotrexate dosage and maintenance over time in the therapy of rheumatoid arthritis patients treated with adalimumab or etanercept: retrospective analysis of a local registry

The role of concomitant methotrexate dosage and maintenance over time in the therapy of rheumatoid...

Por Favalli, Ennio Giulio, Becciolini, Andrea, Biggioggero, Martina, Bertoldi, Ilaria, Crotti, Chiara, Raimondo, Maria Gabriella, Marchesoni, Antonio
Publicado no Drug Des Devel Ther (2018)

“... drug, extracted from a local registry. Enrolled patients were stratified into 3 subgroups according...”
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114

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures

Por Mumoli, Laura, Palleria, Caterina, Gasparini, Sara, Citraro, Rita, Labate, Angelo, Ferlazzo, Edoardo, Gambardella, Antonio, De Sarro, Giovambattista, Russo, Emilio
Publicado no Drug Des Devel Ther (2015)

“... requires dose adjustment. BRV does not seem to influence other antiepileptic drug plasma levels. Six...”
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115

Review of daclizumab and its therapeutic potential in the treatment of relapsing–remitting multiple sclerosis

Review of daclizumab and its therapeutic potential in the treatment of relapsing–remitting multiple sclerosis

Por Reardon, Jennifer, Perumal, Jai S
Publicado em 2013

“.... Since the approval of the first disease-modifying therapy and the initiation of appropriate treatments...”
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116

Axitinib in the treatment of renal cell carcinoma: design, development, and place in therapy

Axitinib in the treatment of renal cell carcinoma: design, development, and place in therapy

Por Bellesoeur, Audrey, Carton, Edith, Alexandre, Jerome, Goldwasser, Francois, Huillard, Olivier
Publicado no Drug Des Devel Ther (2017)

“... or the emergence of check point inhibitors as nivolumab and the place of axitinib in therapy is therefore...”
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117

Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats

Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats

Por Lin, Chien-Min, Tsai, Jo-Ting, Chang, Chen Kuei, Cheng, Juei-Tang, Lin, Jia-Wei
Publicado no Drug Des Devel Ther (2015)

“...-treated rats. Additionally, this action of telmisartan was inhibited by GSK0660 at the dose sufficient...”
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118

Spotlight on opicapone as an adjunct to levodopa in Parkinson’s disease: design, development and potential place in therapy

Spotlight on opicapone as an adjunct to levodopa in Parkinson’s disease: design, development and potential place in therapy

Por Annus, Ádám, Vécsei, László
Publicado no Drug Des Devel Ther (2017)

“... in the nigrostriatal system. Currently, disease-modifying therapies are not available, and levodopa (LD) treatment...”
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119

Inhaled treprostinil: a therapeutic review

Inhaled treprostinil: a therapeutic review

Por Channick, Richard N, Voswinckel, Robert, Rubin, Lewis J
Publicado em 2012

“... to right ventricular failure and often death. Several effective therapies are now available for PAH...”
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120

Adjuvant therapies for Parkinson’s disease: critical evaluation of safinamide

Adjuvant therapies for Parkinson’s disease: critical evaluation of safinamide

Por Stocchi, Fabrizio, Torti, Margherita
Publicado no Drug Des Devel Ther (2016)

“...Safinamide (SAF) is a new drug developed for the treatment of Parkinson’s disease (PD). It is a...”
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