Modifying tetramethyl–nitrophenyl–imidazoline with amino acids: design, synthesis, and 3D-QSAR for improving inflammatory pain therapy

With the help of pharmacophore analysis and docking investigation, 15 novel 1-(4,4,5,5-tetramethyl-2-(3-nitrophenyl)-4,5-dihydroimidazol-1-yl)-oxyacetyl-L-amino acids (6a–o) were designed, synthesized, and assayed. On tail-flick and xylene-induced ear edema models, 10 μmol/kg 6a–o exhibited excellen...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Jiang, Xueyun, Wang, Yuji, Zhu, Haimei, Wang, Yaonan, Zhao, Ming, Zhao, Shurui, Wu, Jianhui, Li, Shan, Peng, Shiqi
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410827/
https://ncbi.nlm.nih.gov/pubmed/25960636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S76218
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