RGDV-modified gemcitabine: a nano-medicine capable of prolonging half-life, overcoming resistance and eliminating bone marrow toxicity of gemcitabine

BACKGROUND: Gemcitabine has been widely used as a chemotherapeutic drug. However, drug resistance, short half-life and side effects seriously decrease its chemotherapeutic efficacy. PURPOSE: The object of preparing RGDV-gemcitabine was to prolong the half-life, to overcome drug resistance and to eli...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Nanomedicine
Hauptverfasser: Liu, Wenchao, Mao, Yujia, Zhang, Xiaoyi, Wang, Yaonan, Wu, Jianhui, Zhao, Shurui, Peng, Shiqi, Zhao, Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove 2019
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737205/
https://ncbi.nlm.nih.gov/pubmed/31686807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S212978
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