Resultados da pesquisa - ((((drug dose) or (drug dna))v) or (((drug dose) or (drug dna)))) devel ther*

1

Is increasing the dose of Entecavir effective in partial virological responders?

Por Erturk, Ayse, Adnan Akdogan, Remzi, Parlak, Emine, Cure, Erkan, Cumhur Cure, Medine, Ozturk, Cinar
Publicado em 2014

“... of the treatment, those with detectable hepatitis B virus (HBV-DNA) were randomized to either ETV 0.5 mg or 1 mg...”
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2

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N-(3-hydroxymethyl-β-carboline-1-yl-ethyl- 2-yl)-l-Phe: development toward a nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation

Por Wu, Jianhui, Zhao, Ming, Wang, Yuji, Wang, Yaonan, Zhu, Haimei, Zhao, Shurui, Gui, Lin, Zhang, Xiaoyi, Peng, Shiqi
Publicado no Drug Des Devel Ther (2017)

“...-selectin is a common target for antithrombotic, anti-inflammatory and antitumor drugs, the aim...”
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3

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High-dose dexamethasone induced LPS-stimulated rat alveolar macrophages apoptosis

Por Zeng, Si, Qiao, Hui, Lv, Xue-wen, Fan, Dan, Liu, Tong, Xie, Dongli
Publicado no Drug Des Devel Ther (2017)

“...Prolonged administration of an excessive dose of corticosteroids proved to be harmful for patients...”
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4

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Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues

Por Ismail, Mohamed A, Arafa, Reem K, Youssef, Magdy M, El-Sayed, Wael M
Publicado em 2014

“... types of cancer. Among the nine types of cancer involved in a five-dose screen, non-small cell lung...”
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5

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DNA stabilization by the upregulation of estrogen signaling in BRCA gene mutation carriers

Por Suba, Zsuzsanna
Publicado no Drug Des Devel Ther (2015)

“... of the BRCA1/2 genes may liberate the proliferative effects of estrogen signaling, which provokes DNA damage...”
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6

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Tenofovir alafenamide in the treatment of chronic hepatitis B: design, development, and place in therapy

Por Ogawa, Eiichi, Furusyo, Norihiro, Nguyen, Mindie H
Publicado no Drug Des Devel Ther (2017)

“... replication at a low dose, with high intracellular concentration and more than 90% lower systemic TFV...”
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7

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Rucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer

Por Colombo, Ilaria, Lheureux, Stephanie, Oza, Amit Manulal
Publicado no Drug Des Devel Ther (2018)

“... (PARP-1, PARP-2 and PARP-3) that play an important role in repairing DNA damage and maintaining genomic...”
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8

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A 6-month mixed-effect pharmacokinetic model for post-transplant intravenous anti-hepatitis B immunoglobulin prophylaxis

Por Han, Seunghoon, Na, Gun Hyung, Kim, Dong-Goo
Publicado no Drug Des Devel Ther (2017)

“...) therapy have been suggested, the pharmacokinetic profile and factors influencing the basis...”
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9

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Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells

Por Dai, Zhi-Jun, Gao, Jie, Kang, Hua-Feng, Ma, Yu-Guang, Ma, Xiao-Bin, Lu, Wang-Feng, Lin, Shuai, Ma, Hong-Bing, Wang, Xi-Jing, Wu, Wen-Ying
Publicado em 2013

“... showing that RPM sensitizes cancers to chemotherapy and radiation therapy have attracted considerable...”
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10

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Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

Por Ali, Norlaily Mohd, Akhtar, M Nadeem, Ky, Huynh, Lim, Kian Lam, Abu, Nadiah, Zareen, Seema, Ho, Wan Yong, Alan-Ong, Han Kiat, Tan, Sheau Wei, Alitheen, Noorjahan Banu, Ismail, Jamil bin, Yeap, Swee Keong, Kamarul, Tunku
Publicado no Drug Des Devel Ther (2016)

“... potential therapeutic value for flavokawain derivative FLS to be further developed as a new anticancer drug....”
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Influence of caffeine and hyaluronic acid on collagen biosynthesis in human skin fibroblasts

Por Donejko, Magdalena, Przylipiak, Andrzej, Rysiak, Edyta, Głuszuk, Katarzyna, Surażyński, Arkadiusz
Publicado em 2014

“... fibroblast cultures that had been treated with 1, 2, and 5 mM caffeine and with caffeine and 500 μg/mL HA...”
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12

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Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines

Por Youssef, Magdy M, Arafa, Reem K, Ismail, Mohamed A
Publicado no Drug Des Devel Ther (2016)

“... in a five-dose screening assay to determine their compound concentration causing 50% growth inhibition...”
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Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells

Por Brard, Laurent, Singh, Rakesh K, Kim, Kyu Kwang, Lange, Thilo S, Sholler, Giselle L Saulier
Publicado em 2009

“... condensation and DNA fragmentation, whereas Annexin-v/7AADstaining revealed that the majority of cells...”
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14

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Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models

Por Paydar, Mohammadjavad, Kamalidehghan, Behnam, Wong, Yi Li, Wong, Won Fen, Looi, Chung Yeng, Mustafa, Mohd Rais
Publicado em 2014

“...To date, plants have been the major source of anticancer drugs. Boldine is a natural alkaloid...”
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The pitfall of the transient, inconsistent anticancer capacity of antiestrogens and the mechanism of apparent antiestrogen resistance

Por Suba, Zsuzsanna
Publicado no Drug Des Devel Ther (2015)

“...Although antiestrogens have been available for breast cancer therapy since the early 1970s, neither...”
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Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2...

Por Perng, Daw-Shyong, Tsai, Yu-Hsin, Cherng, Jonathan, Wang, Jeng-Shing, Chou, Kuo-Shen, Shih, Chia-Wen, Cherng, Jaw-Ming
Publicado no Drug Des Devel Ther (2016)

“...-3 and caspase-9, increase in the DNA content in sub-G1, and morphological characteristics...”
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Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts

Por Donejko, Magdalena, Przylipiak, Andrzej, Rysiak, Edyta, Miltyk, Wojciech, Galicka, Elżbieta, Przylipiak, Jerzy, Zaręba, Ilona, Surazynski, Arkadiusz
Publicado no Drug Des Devel Ther (2015)

“.... MATERIALS AND METHODS: Collagen biosynthesis, activity of prolidase, DNA biosynthesis, and cytotoxicity were...”
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Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells

Por Lin, Ji-Fan, Lin, Yi-Chia, Tsai, Te-Fu, Chen, Hung-En, Chou, Kuang-Yu, Hwang, Thomas I-Sheng
Publicado no Drug Des Devel Ther (2017)

“... cancer; and a high basal level of autophagy has been demonstrated in human bladder tumors. Therefore...”
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Novel production method of innovative antiangiogenic and antitumor small peptides in Escherichia coli

Por Setrerrahmane, Sarra, Yu, Jian, Hao, Jingchao, Zheng, Heng, Xu, Hanmei
Publicado no Drug Des Devel Ther (2017)

“... an ongoing task in antitumor therapy development. In the last few years, peptide drugs have become attractive...”
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