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DNA stabilization by the upregulation of estrogen signaling in BRCA gene mutation carriers

Currently available scientific evidence erroneously suggests that mutagenic weakness or loss of the BRCA1/2 genes may liberate the proliferative effects of estrogen signaling, which provokes DNA damage and genomic instability. Conversely, BRCA mutation seems to be an imbalanced defect, crudely inhib...

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Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Glavni avtor: Suba, Zsuzsanna
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440422/
https://ncbi.nlm.nih.gov/pubmed/26028963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S84437
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