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DNA stabilization by the upregulation of estrogen signaling in BRCA gene mutation carriers
Currently available scientific evidence erroneously suggests that mutagenic weakness or loss of the BRCA1/2 genes may liberate the proliferative effects of estrogen signaling, which provokes DNA damage and genomic instability. Conversely, BRCA mutation seems to be an imbalanced defect, crudely inhib...
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| Publicado no: | Drug Des Devel Ther |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4440422/ https://ncbi.nlm.nih.gov/pubmed/26028963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S84437 |
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