Resultados da pesquisa - ((((drug de) OR (drug dna))v) or (((drug de) OR (drug dna)))) devel ther*

81

Synthesis, structural characterization, and anticancer activity of a monobenzyltin compound against MCF-7 breast cancer cells

Por Fani, Somayeh, Kamalidehghan, Behnam, Lo, Kong Mun, Hashim, Najihah Mohd, Chow, Kit May, Ahmadipour, Fatemeh
Publicado no Drug Des Devel Ther (2015)

“...A new monoorganotin Schiff base compound, [N-(3,5-dichloro-2-oxidobenzylidene)-4...”
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82

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Prevalence of the CYP2D6*10 (C100T), *4 (G1846A), and *14 (G1758A) alleles among Iranians of different ethnicities

Por Bagheri, Ali, Kamalidehghan, Behnam, Haghshenas, Maryam, Azadfar, Parisa, Akbari, Leila, Sangtarash, Mohammad Hossein, Vejdandoust, Faramarz, Ahmadipour, Fatemeh, Meng, Goh Yong, Houshmand, Massoud
Publicado no Drug Des Devel Ther (2015)

“... the information would be helpful for clinicians to optimize therapy or identify persons at risk of adverse drug...”
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83

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Cytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis

Por Wu, Jianghong, Wang, Yuren, Liang, Shuguang, Ma, Haiching
Publicado em 2014

“... for reducing the side effects of cancer therapy and for control of neurodegenerative disorders...”
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84

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Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated...

Por Ren, Tao, Shan, Jinlu, Qing, Yi, Qian, Chengyuan, Li, Qing, Lu, Guoshou, Li, Mengxia, Li, Chongyi, Peng, Yu, Luo, Hao, Zhang, Shiheng, Zhang, Weiwei, Wang, Dong, Zhou, Shu-Feng
Publicado no Drug Des Devel Ther (2014)

“... the STAT3–DNA binding; and reducing the expression of the downstream antiapoptotic proteins Bcl-2 and Bcl...”
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85

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Novel A20-gene-eluting stent inhibits carotid artery restenosis in a porcine model

Por Zhou, Zhen-hua, Peng, Jing, Meng, Zhao-you, Chen, Lin, Huang, Jia-Lu, Huang, He-qing, Li, Li, Zeng, Wen, Wei, Yong, Zhu, Chu-Hong, Chen, Kang-Ning
Publicado no Drug Des Devel Ther (2016)

“... and anti-DNA immunoglobulin fixation. Anti-restenosis effects of modified vs control (the bare-metal stent...”
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86

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Decitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis

Por Zhang, Nan, Liu, Yanyang, Wang, Yuyi, Zhao, Maoyuan, Tu, Li, Luo, Feng
Publicado no Drug Des Devel Ther (2017)

“... of EMT may, therefore, represent a promising approach in anticancer treatment. METHODS: In this study, we...”
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87

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A 6-month mixed-effect pharmacokinetic model for post-transplant intravenous anti-hepatitis B immunoglobulin prophylaxis

Por Han, Seunghoon, Na, Gun Hyung, Kim, Dong-Goo
Publicado no Drug Des Devel Ther (2017)

“...) therapy have been suggested, the pharmacokinetic profile and factors influencing the basis...”
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88

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Intestinal absorption and biliary elimination of glycyrrhizic acid diethyl ester in rats

Por Koga, Kenjiro, Kawamura, Mayuri, Iwase, Hiroshi, Yoshikawa, Nobuji
Publicado em 2013

“... the gastrointestinal tract of glycyrrhizic acid diethyl ester (GZ-DE) which was prepared as a prodrug of glycyrrhizic...”
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89

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Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells

Por Brard, Laurent, Singh, Rakesh K, Kim, Kyu Kwang, Lange, Thilo S, Sholler, Giselle L Saulier
Publicado em 2009

“... condensation and DNA fragmentation, whereas Annexin-v/7AADstaining revealed that the majority of cells...”
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90

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Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models

Por Paydar, Mohammadjavad, Kamalidehghan, Behnam, Wong, Yi Li, Wong, Won Fen, Looi, Chung Yeng, Mustafa, Mohd Rais
Publicado em 2014

“...To date, plants have been the major source of anticancer drugs. Boldine is a natural alkaloid...”
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91

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Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor

Por Qian, Chengyuan, Li, Mengxia, Sui, Jiangdong, Ren, Tao, Li, Zheng, Zhang, Liang, Zhou, Liwei, Cheng, Yi, Wang, Dong
Publicado em 2014

“... multifunctional protein involved in the repair of oxidative deoxyribonucleic acid (DNA) damage and transcriptional...”
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92

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Anti-proliferative, apoptotic induction, and anti-migration effects of hemi-synthetic 1′S-1′-acetoxychavicol acetate analogs on MDA-MB-231 breast cancer cells

Por Liew, Su Ki, Azmi, Mohamad Nurul, In, Lionel LA, Awang, Khalijah, Nagoor, Noor Hasima
Publicado no Drug Des Devel Ther (2017)

“... (AEA), and 1′-acetoxy-3,5-dimethoxychavicol acetate (AMCA) inhibited the growth of MDA-MB-231 breast...”
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93

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Notoginsenoside R1 attenuates high glucose-induced endothelial damage in rat retinal capillary endothelial cells by modulating the intracellular redox state

Por Fan, Chunlan, Qiao, Yuan, Tang, Minke
Publicado no Drug Des Devel Ther (2017)

“... cytotoxicity, including decreased cell viability, reduced mitochondrial DNA copy number, increased lactate...”
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94

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Novel production method of innovative antiangiogenic and antitumor small peptides in Escherichia coli

Por Setrerrahmane, Sarra, Yu, Jian, Hao, Jingchao, Zheng, Heng, Xu, Hanmei
Publicado no Drug Des Devel Ther (2017)

“... an ongoing task in antitumor therapy development. In the last few years, peptide drugs have become attractive...”
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95

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A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells

Por Zhou, Yanfang, Li, Jiemei, Lu, Fang, Deng, Junjie, Zhang, Jiahua, Fang, Peijie, Peng, Xinsheng, Zhou, Shu-Feng
Publicado no Drug Des Devel Ther (2015)

“... exhibited a better water solubility and enhanced plasmid DNA transfection efficiency. In this study, we...”
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96

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Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of advanced atherosclerosis

Por Sievers, Philipp, Uhlmann, Lorenz, Korkmaz-Icöz, Sevil, Fastner, Christian, Bea, Florian, Blessing, Erwin, Katus, Hugo A, Preusch, Michael R
Publicado no Drug Des Devel Ther (2015)

“... disease, at the time when medical treatment is started, are already well established. Therefore, we set up...”
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97

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Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2...

Por Perng, Daw-Shyong, Tsai, Yu-Hsin, Cherng, Jonathan, Wang, Jeng-Shing, Chou, Kuo-Shen, Shih, Chia-Wen, Cherng, Jaw-Ming
Publicado no Drug Des Devel Ther (2016)

“...-3 and caspase-9, increase in the DNA content in sub-G1, and morphological characteristics...”
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98

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Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines

Por Youssef, Magdy M, Arafa, Reem K, Ismail, Mohamed A
Publicado no Drug Des Devel Ther (2016)

“... in a five-dose screening assay to determine their compound concentration causing 50% growth inhibition...”
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99

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Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation

Por Zhan, Weili, Kang, Yanhong, Chen, Ning, Mao, Chongshan, Kang, Yi, Shang, Jia
Publicado no Drug Des Devel Ther (2017)

“... of serum hepatitis B e-antigen, hepatitis B surface antigen, and HBV DNA induced by HBV infection. HF also...”
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100

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Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts

Por Donejko, Magdalena, Przylipiak, Andrzej, Rysiak, Edyta, Miltyk, Wojciech, Galicka, Elżbieta, Przylipiak, Jerzy, Zaręba, Ilona, Surazynski, Arkadiusz
Publicado no Drug Des Devel Ther (2015)

“.... MATERIALS AND METHODS: Collagen biosynthesis, activity of prolidase, DNA biosynthesis, and cytotoxicity were...”
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