Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor

The human apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (APE1/Ref-1), an essential multifunctional protein involved in the repair of oxidative deoxyribonucleic acid (DNA) damage and transcriptional regulation, is often overexpressed in tumor tissues and cancer cells. Moreover, APE1/R...

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Detalhes bibliográficos
Main Authors: Qian, Chengyuan, Li, Mengxia, Sui, Jiangdong, Ren, Tao, Li, Zheng, Zhang, Liang, Zhou, Liwei, Cheng, Yi, Wang, Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026309/
https://ncbi.nlm.nih.gov/pubmed/24872679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S62963
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