TPF induction chemotherapy increases PD-L1 expression in tumour cells and immune cells in head and neck squamous cell carcinoma

Por Leduc, Charlotte, Adam, Julien, Louvet, Emilie, Sourisseau, Tony, Dorvault, Nicolas, Bernard, Marine, Maingot, Elodie, Faivre, Laura, Cassin-Kuo, Mei-Shiue, Boissier, Emilie, Dessoliers, Marie-Charlotte, Robin, Angélique, Casiraghi, Odile, Even, Caroline, Temam, Stéphane, Olaussen, Ken A, Soria, Jean-Charles, Postel-Vinay, Sophie
Publicado no ESMO Open (2018)

Immune checkpoint inhibition-related colitis: symptoms, endoscopic features, histology and response to management

Por Geukes Foppen, Marnix H, Rozeman, Elisa A, van Wilpe, Sandra, Postma, Cindy, Snaebjornsson, Petur, van Thienen, Johannes V, van Leerdam, Monique E, van den Heuvel, Michel, Blank, Christian U, van Dieren, Jolanda, Haanen, John B A G
Publicado no ESMO Open (2018)

Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case

Por Martinelli, Erika, Troiani, Teresa, Sforza, Vincenzo, Martini, Giulia, Cardone, Claudia, Vitiello, Pietro Paolo, Ciardiello, Davide, Rachiglio, Anna Maria, Normanno, Nicola, Sartore-Bianchi, Andrea, Marsoni, Silvia, Bardelli, Alberto, Siena, Salvatore, Ciardiello, Fortunato
Publicado no ESMO Open (2018)

Phase I study of tomuzotuximab, a glycoengineered therapeutic antibody against the epidermal growth factor receptor, in patients with advanced carcinomas

Por Fiedler, Walter, Cresta, Sara, Schulze-Bergkamen, Henning, De Dosso, Sara, Weidmann, Jens, Tessari, Anna, Baumeister, Hans, Danielczyk, Antje, Dietrich, Bruno, Goletz, Steffen, Zurlo, Alfredo, Salzberg, Marc, Sessa, Cristiana, Gianni, Luca
Publicado no ESMO Open (2018)

Phase I study of the investigational oral mTORC1/2 inhibitor sapanisertib (TAK-228): tolerability and food effects of a milled formulation in patients with advanced solid tumours

Por Moore, Kathleen N, Bauer, Todd M, Falchook, Gerald S, Chowdhury, Swapan, Patel, Chirag, Neuwirth, Rachel, Enke, Aaron, Zohren, Fabian, Patel, Manish R
Publicado no ESMO Open (2018)

Updated survival outcomes of NEJ005/TCOG0902: a randomised phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small c...

Por Oizumi, Satoshi, Sugawara, Shunichi, Minato, Koichi, Harada, Toshiyuki, Inoue, Akira, Fujita, Yuka, Maemondo, Makoto, Watanabe, Satoshi, Ito, Kazuhiko, Gemma, Akihiko, Demura, Yoshiki, Fukumoto, Shinichi, Isobe, Hiroshi, Kinoshita, Ichiro, Morita, Satoshi, Kobayashi, Kunihiko, Hagiwara, Koichi, Aiba, Keisuke, Nukiwa, Toshihiro
Publicado no ESMO Open (2018)

Contemporary outcomes from the use of regular imaging to detect relapse in high-risk cutaneous melanoma

Por Lim, Kok Haw Jonathan, Spain, Lavinia, Barker, Claire, Georgiou, Alexandros, Walls, Gerard, Gore, Martin, Turajlic, Samra, Board, Ruth, Larkin, James M, Lorigan, Paul
Publicado no ESMO Open (2018)

Chemotherapy in cancer patients undergoing haemodialysis: a nationwide study in Japan

Por Funakoshi, Taro, Horimatsu, Takahiro, Nakamura, Michio, Shiroshita, Koichi, Suyama, Koichi, Mukoyama, Masashi, Mizukami, Takuro, Sakurada, Tsutomu, Baba, Eishi, Tsuruya, Kazuhiko, Nozaki, Akira, Yahata, Kensei, Ozaki, Yukinori, Ubara, Yoshifumi, Yasui, Hisateru, Yoshimoto, Akihiro, Fukuma, Shingo, Kondo, Naoya, Matsubara, Takeshi, Matsubara, Kazuo, Fukuhara, Shunichi, Yanagita, Motoko, Muto, Manabu
Publicado no ESMO Open (2018)

Four distinct immune microenvironment subtypes in gastric adenocarcinoma with special reference to microsatellite instability

Por Cho, Junhun, Chang, Young Hwan, Heo, You Jeong, Kim, Seungtae, Kim, Nayoung KD, Park, Joon Oh, Kang, Won Ki, Lee, Jeeyun, Kim, Kyoung-Mee
Publicado no ESMO Open (2018)

Relevance of a molecular tumour board (MTB) for patients’ enrolment in clinical trials: experience of the Institut Curie

Por Basse, Clémence, Morel, Claire, Alt, Marie, Sablin, Marie Paule, Franck, Coralie, Pierron, Gaëlle, Callens, Céline, Melaabi, Samia, Masliah-Planchon, Julien, Bataillon, Guillaume, Gardrat, Sophie, Lavigne, Marion, Bonsang, Benjamin, Vaflard, Pauline, Pons Tostivint, Elvire, Dubot, Coraline, Loirat, Delphine, Marous, Miguelle, Geiss, Romain, Clément, Nathalie, Schleiermacher, Gudrun, Kamoun, Choumouss, Girard, Elodie, Ardin, Maude, Benoist, Camille, Bernard, Virginie, Mariani, Odette, Rouzier, Roman, Tresca, Patricia, Servois, Vincent, Vincent-Salomon, Anne, Bieche, Ivan, Le Tourneau, Christophe, Kamal, Maud
Publicado no ESMO Open (2018)

Comprehensive molecular screening by next generation sequencing reveals a distinctive mutational profile of KIT/PDGFRA genes and novel genomic alterations: results from a 20-year c...

Por Mavroeidis, Leonidas, Metaxa-Mariatou, Vassiliki, Papoudou-Bai, Alexandra, Lampraki, Angeliki Maria, Kostadima, Lida, Tsinokou, Ilias, Zarkavelis, George, Papadaki, Alexandra, Petrakis, Dimitrios, Gκoura, Stefania, Kampletsas, Eleftherios, Nasioulas, George, Batistatou, Anna, Pentheroudakis, George
Publicado no ESMO Open (2018)

Safety data from the phase III Japanese ACHIEVE trial: part of an international, prospective, planned pooled analysis of six phase III trials comparing 3 versus 6 months of oxalipl...

Por Kotaka, Masahito, Yamanaka, Takeharu, Yoshino, Takayuki, Manaka, Dai, Eto, Tetsuya, Hasegawa, Junichi, Takagane, Akinori, Nakamura, Masato, Kato, Takeshi, Munemoto, Yoshinori, Nakamura, Fumitaka, Bando, Hiroyuki, Taniguchi, Hiroki, Gamoh, Makio, Shiozawa, Manabu, Saji, Shigetoyo, Maehara, Yoshihiko, Mizushima, Tsunekazu, Ohtsu, Atsushi, Mori, Masaki
Publicado no ESMO Open (2018)

Patient-reported outcomes in a phase II, North American study of alectinib in patients with ALK-positive, crizotinib-resistant, non-small cell lung cancer

Por Ou, Sai-Hong Ignatius, Socinski, Mark A, Gadgeel, Shirish, Gandhi, Leena, West, Howard, Chiappori, Alberto Alejandro, Cohen, Victor, Riely, Gregory J, Smoljanovic, Vlatka, Bordogna, Walter, Wright, Elaine, Debusk, Kendra, Zeaiter, Ali, Shaw, Alice T
Publicado no ESMO Open (2018)

TRIPLETE: a randomised phase III study of modified FOLFOXIRI plus panitumumab versus mFOLFOX6 plus panitumumab as initial therapy for patients with unresectable RAS and BRAF wild-t...

Por Borelli, Beatrice, Moretto, Roberto, Lonardi, Sara, Bonetti, Andrea, Antoniotti, Carlotta, Pietrantonio, Filippo, Masi, Gianluca, Burgio, Valentina, Marmorino, Federica, Salvatore, Lisa, Rossini, Daniele, Zaniboni, Alberto, Zucchelli, Gemma, Martignetti, Angelo, Di Battista, Monica, Pella, Nicoletta, Passardi, Alessandro, Boccaccino, Alessandra, Leone, Francesco, Colombo, Camilla, Granetto, Cristina, Vannini, Francesca, Marsico, Valentina Angela, Martinelli, Erika, Antonuzzo, Lorenzo, Vitello, Stefano, Delliponti, Laura, Boni, Luca, Cremolini, Chiara, Falcone, Alfredo
Publicado no ESMO Open (2018)

Phase II study assessing the benefit of cisplatin re-introduction (stop-and-go strategy) in patients with advanced non-squamous non-small cell lung cancer: the IFCT-1102 BUCiL stud...

Por Bennouna, Jaafar, Barlesi, Fabrice, Do, Pascal, Dumont, Patrick, Cadranel, Jacques, Debieuvre, Didier, Hilgers, Werner, Molinier, Olivier, Quoix, Elisabeth, Raimbourg, Judith, Langlais, Alexandra, Morin, Franck, Souquet, Pierre-Jean
Publicado no ESMO Open (2018)

Association of homogeneous inflamed gene signature with a better outcome in patients with metastatic melanoma treated with MAGE-A3 immunotherapeutic

Por Baurain, Jean-François, Robert, Caroline, Mortier, Laurent, Neyns, Bart, Grange, Florent, Lebbe, Céleste, Ulloa-Montoya, Fernando, De Sousa Alves, Pedro Miguel, Gillet, Marc, Louahed, Jamila, Jarnjak, Silvija, Lehmann, Frédéric F
Publicado no ESMO Open (2018)

Real-world features associated with cancer-related venous thromboembolic events

Por Peippo, Maija Helena, Kurki, Samu, Lassila, Riitta, Carpén, Olli Mikael
Publicado no ESMO Open (2018)

NanoString expression profiling identifies candidate biomarkers of RAD001 response in metastatic gastric cancer

Por Das, Kakoli, Chan, Xiu Bin, Epstein, David, Teh, Bin Tean, Kim, Kyoung-Mee, Kim, Seung Tae, Park, Se Hoon, Kang, Won Ki, Rozen, Steve, Lee, Jeeyun, Tan, Patrick
Publicado no ESMO Open (2016)

Efficacy and toxicity of adjuvant chemotherapy in elderly patients with colorectal cancer: the ACCORE study

Por Lund, C M, Nielsen, D, Dehlendorff, C, Christiansen, A B, Rønholt, F, Johansen, J S, Vistisen, K K
Publicado no ESMO Open (2016)

Multicentre phase II study of nivolumab in Japanese patients with advanced or recurrent non-squamous non-small cell lung cancer

Por Nishio, Makoto, Hida, Toyoaki, Atagi, Shinji, Sakai, Hiroshi, Nakagawa, Kazuhiko, Takahashi, Toshiaki, Nogami, Naoyuki, Saka, Hideo, Takenoyama, Mitsuhiro, Maemondo, Makoto, Ohe, Yuichiro, Nokihara, Hiroshi, Hirashima, Tomonori, Tanaka, Hiroshi, Fujita, Shiro, Takeda, Koji, Goto, Koichi, Satouchi, Miyako, Isobe, Hiroshi, Minato, Koichi, Sumiyoshi, Naoki, Tamura, Tomohide
Publicado no ESMO Open (2017)