Comprehensive molecular screening by next generation sequencing reveals a distinctive mutational profile of KIT/PDGFRA genes and novel genomic alterations: results from a 20-year cohort of patients with GIST from north-western Greece

INTRODUCTION: Gastrointestinal stromal tumours (GIST) are mesenchymal neoplasms that usually carry an activating mutation in KIT or platelet-derived growth factor receptor alpha (PDGFRA) genes with predictive and prognostic significance. We investigated the extended mutational status of GIST in a pa...

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Publicado no:ESMO Open
Main Authors: Mavroeidis, Leonidas, Metaxa-Mariatou, Vassiliki, Papoudou-Bai, Alexandra, Lampraki, Angeliki Maria, Kostadima, Lida, Tsinokou, Ilias, Zarkavelis, George, Papadaki, Alexandra, Petrakis, Dimitrios, Gκoura, Stefania, Kampletsas, Eleftherios, Nasioulas, George, Batistatou, Anna, Pentheroudakis, George
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890860/
https://ncbi.nlm.nih.gov/pubmed/29636989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/esmoopen-2018-000335
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