Methylation-Mediated Proviral Silencing Is Associated with MeCP2 Recruitment and Localized Histone H3 Deacetylation

The majority of 5-methylcytosine in mammalian DNA resides in endogenous transposable elements and is associated with the transcriptional silencing of these parasitic elements. Methylation also plays an important role in the silencing of exogenous retroviruses. One of the difficulties inherent in the...

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Bibliographic Details
Main Authors: Lorincz, Matthew C., Schübeler, Dirk, Groudine, Mark
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC99960/
https://ncbi.nlm.nih.gov/pubmed/11689684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.23.7913-7922.2001
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