Targeted Disruption of the Transition Protein 2 Gene Affects Sperm Chromatin Structure and Reduces Fertility in Mice

During mammalian spermiogenesis, major restructuring of chromatin takes place. In the mouse, the histones are replaced by the transition proteins, TP1 and TP2, which are in turn replaced by the protamines, P1 and P2. To investigate the role of TP2, we generated mice with a targeted deletion of its g...

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מידע ביבליוגרפי
Main Authors: Zhao, Ming, Shirley, Cynthia R., Yu, Y. Eugene, Mohapatra, Bhagyalaxmi, Zhang, Yun, Unni, Emmanual, Deng, Jian M., Arango, Nelson A., Terry, Nicholas H. A., Weil, Michael M., Russell, Lonnie D., Behringer, Richard R., Meistrich, Marvin L.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2001
נושאים:
Mammalian Genetic Models with Minimal or Complex Phenotypes
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC99899/
https://ncbi.nlm.nih.gov/pubmed/11585907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.21.7243-7255.2001
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