Targeted Disruption of the Transition Protein 2 Gene Affects Sperm Chromatin Structure and Reduces Fertility in Mice

During mammalian spermiogenesis, major restructuring of chromatin takes place. In the mouse, the histones are replaced by the transition proteins, TP1 and TP2, which are in turn replaced by the protamines, P1 and P2. To investigate the role of TP2, we generated mice with a targeted deletion of its g...

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Autori principali: Zhao, Ming, Shirley, Cynthia R., Yu, Y. Eugene, Mohapatra, Bhagyalaxmi, Zhang, Yun, Unni, Emmanual, Deng, Jian M., Arango, Nelson A., Terry, Nicholas H. A., Weil, Michael M., Russell, Lonnie D., Behringer, Richard R., Meistrich, Marvin L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC99899/
https://ncbi.nlm.nih.gov/pubmed/11585907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.21.7243-7255.2001
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