Targeted Disruption of the Transition Protein 2 Gene Affects Sperm Chromatin Structure and Reduces Fertility in Mice

During mammalian spermiogenesis, major restructuring of chromatin takes place. In the mouse, the histones are replaced by the transition proteins, TP1 and TP2, which are in turn replaced by the protamines, P1 and P2. To investigate the role of TP2, we generated mice with a targeted deletion of its g...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Zhao, Ming, Shirley, Cynthia R., Yu, Y. Eugene, Mohapatra, Bhagyalaxmi, Zhang, Yun, Unni, Emmanual, Deng, Jian M., Arango, Nelson A., Terry, Nicholas H. A., Weil, Michael M., Russell, Lonnie D., Behringer, Richard R., Meistrich, Marvin L.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2001
الموضوعات:
Mammalian Genetic Models with Minimal or Complex Phenotypes
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC99899/
https://ncbi.nlm.nih.gov/pubmed/11585907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.21.7243-7255.2001
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