Targeted Disruption of the Transition Protein 2 Gene Affects Sperm Chromatin Structure and Reduces Fertility in Mice

During mammalian spermiogenesis, major restructuring of chromatin takes place. In the mouse, the histones are replaced by the transition proteins, TP1 and TP2, which are in turn replaced by the protamines, P1 and P2. To investigate the role of TP2, we generated mice with a targeted deletion of its g...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Zhao, Ming, Shirley, Cynthia R., Yu, Y. Eugene, Mohapatra, Bhagyalaxmi, Zhang, Yun, Unni, Emmanual, Deng, Jian M., Arango, Nelson A., Terry, Nicholas H. A., Weil, Michael M., Russell, Lonnie D., Behringer, Richard R., Meistrich, Marvin L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC99899/
https://ncbi.nlm.nih.gov/pubmed/11585907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.21.7243-7255.2001
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados