Targeted Disruption of the Transition Protein 2 Gene Affects Sperm Chromatin Structure and Reduces Fertility in Mice

During mammalian spermiogenesis, major restructuring of chromatin takes place. In the mouse, the histones are replaced by the transition proteins, TP1 and TP2, which are in turn replaced by the protamines, P1 and P2. To investigate the role of TP2, we generated mice with a targeted deletion of its g...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhao, Ming, Shirley, Cynthia R., Yu, Y. Eugene, Mohapatra, Bhagyalaxmi, Zhang, Yun, Unni, Emmanual, Deng, Jian M., Arango, Nelson A., Terry, Nicholas H. A., Weil, Michael M., Russell, Lonnie D., Behringer, Richard R., Meistrich, Marvin L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2001
Konular:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC99899/
https://ncbi.nlm.nih.gov/pubmed/11585907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.21.7243-7255.2001
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