Arsenic Trioxide Is a Potent Inhibitor of the Interaction of SMRT Corepressor with Its Transcription Factor Partners, Including the PML-Retinoic Acid Receptor α Oncoprotein Found in Human Acute Promyelocytic Leukemia

The SMRT corepressor complex participates in transcriptional repression by a diverse array of vertebrate transcription factors. The ability to recruit SMRT appears to play a crucial role in leukemogenesis by the PML-retinoic acid receptor α (RARα) oncoprotein, an aberrant nuclear hormone receptor im...

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Detalles Bibliográficos
Main Authors: Hong, Suk-Hyun, Yang, Zhihong, Privalsky, Martin L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Transcriptional Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC99892/
https://ncbi.nlm.nih.gov/pubmed/11585900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.21.7172-7182.2001
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