ETO, a Target of t(8;21) in Acute Leukemia, Makes Distinct Contacts with Multiple Histone Deacetylases and Binds mSin3A through Its Oligomerization Domain

t(8;21) and t(16;21) create two fusion proteins, AML-1–ETO and AML-1–MTG16, respectively, which fuse the AML-1 DNA binding domain to putative transcriptional corepressors, ETO and MTG16. Here, we show that distinct domains of ETO contact the mSin3A and N-CoR corepressors and define two binding sites...

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Detalhes bibliográficos
Main Authors: Amann, Joseph M., Nip, John, Strom, David K., Lutterbach, Bart, Harada, Hironori, Lenny, Noel, Downing, James R., Meyers, Shari, Hiebert, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC99794/
https://ncbi.nlm.nih.gov/pubmed/11533236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.19.6470-6483.2001
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