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ETO, a Target of t(8;21) in Acute Leukemia, Makes Distinct Contacts with Multiple Histone Deacetylases and Binds mSin3A through Its Oligomerization Domain

t(8;21) and t(16;21) create two fusion proteins, AML-1–ETO and AML-1–MTG16, respectively, which fuse the AML-1 DNA binding domain to putative transcriptional corepressors, ETO and MTG16. Here, we show that distinct domains of ETO contact the mSin3A and N-CoR corepressors and define two binding sites...

Deskribapen osoa

Gorde:
Argitaratua izan da:Mol Cell Biol
Egile Nagusiak: Amann, Joseph M., Nip, John, Strom, David K., Lutterbach, Bart, Harada, Hironori, Lenny, Noel, Downing, James R., Meyers, Shari, Hiebert, Scott W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2001
Gaiak:
Transcriptional Regulation
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99794/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11533236/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.19.6470-6483.2001
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