Oligomerization of ETO Is Obligatory for Corepressor Interaction

Nearly 40% of cases of acute myelogenous leukemia (AML) of the M2 subtype are due to a chromosomal translocation that combines a sequence-specific DNA binding protein, AML1, with a potent transcriptional repressor, ETO. ETO interacts with nuclear receptor corepressors SMRT and N-CoR, which recruit h...

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Autors principals: Zhang, Jinsong, Hug, Bruce A., Huang, Eric Y., Chen, Clarice W., Gelmetti, Vania, Maccarana, Marco, Minucci, Saverio, Pelicci, Pier Giuseppe, Lazar, Mitchell A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Transcriptional Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC88789/
https://ncbi.nlm.nih.gov/pubmed/11113190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.1.156-163.2001
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