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Shared Pathways of IκB Kinase-Induced SCF(βTrCP)-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα

p105 (NFKB1) acts in a dual way as a cytoplasmic IκB molecule and as the source of the NF-κB p50 subunit upon processing. p105 can form various heterodimers with other NF-κB subunits, including its own processing product, p50, and these complexes are signal responsive. Signaling through the IκB kina...

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Udgivet i:Mol Cell Biol
Principais autores: Heissmeyer, Vigo, Krappmann, Daniel, Hatada, Eunice N., Scheidereit, Claus
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2001
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99557/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158290/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.4.1024-1035.2001
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