Codon Optimization of Gene Fragments Encoding Plasmodium falciparum Merzoite Proteins Enhances DNA Vaccine Protein Expression and Immunogenicity in Mice

In contrast to conventional vaccines, DNA and other subunit vaccines exclusively utilize host cell molecules for transcription and translation of proteins. The adenine plus thymine content of Plasmodium falciparum gene sequences (∼80%) is much greater than that of Homo sapiens (∼59%); consequently,...

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Bibliographische Detailangaben
Hauptverfasser: Narum, David L., Kumar, Sanjai, Rogers, William O., Fuhrmann, Steven R., Liang, Hong, Oakley, Miranda, Taye, Alem, Sim, B. Kim Lee, Hoffman, Stephen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Fungal and Parasitic Infections
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC98808/
https://ncbi.nlm.nih.gov/pubmed/11705894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.12.7250-7253.2001
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