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CD85/LIR-1/ILT2 and CD152 (Cytotoxic T Lymphocyte Antigen 4) Inhibitory Molecules Down-Regulate the Cytolytic Activity of Human CD4(+) T-Cell Clones Specific for Mycobacterium tuberculosis
Antigen-specific cytolytic CD4(+) T lymphocytes control Mycobacterium tuberculosis infection by secreting cytokines and by killing macrophages that have phagocytosed the pathogen. However, lysis of the latter cells promotes microbial dissemination, and other macrophages engulf the released bacteria....
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC98730/ https://ncbi.nlm.nih.gov/pubmed/11553539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.10.6022-6029.2001 |
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