Intranasal Immunization with Killed Unencapsulated Whole Cells Prevents Colonization and Invasive Disease by Capsulated Pneumococci

A whole-cell killed unencapsulated pneumococcal vaccine given by the intranasal route with cholera toxin as an adjuvant was tested in two animal models. This vaccination was highly effective in preventing nasopharyngeal colonization with an encapsulated serotype 6B strain in mice and also conferred...

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Главные авторы: Malley, Richard, Lipsitch, Marc, Stack, Anne, Saladino, Richard, Fleisher, Gary, Pelton, Steven, Thompson, Claudette, Briles, David, Anderson, Porter
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2001
Предметы:
Microbial Immunity and Vaccines
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC98576/
https://ncbi.nlm.nih.gov/pubmed/11447162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.8.4870-4873.2001
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