Intranasal Immunization with Killed Unencapsulated Whole Cells Prevents Colonization and Invasive Disease by Capsulated Pneumococci

A whole-cell killed unencapsulated pneumococcal vaccine given by the intranasal route with cholera toxin as an adjuvant was tested in two animal models. This vaccination was highly effective in preventing nasopharyngeal colonization with an encapsulated serotype 6B strain in mice and also conferred...

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Argitaratua izan da:	Infect Immun
Egile Nagusiak:	Malley, Richard, Lipsitch, Marc, Stack, Anne, Saladino, Richard, Fleisher, Gary, Pelton, Steven, Thompson, Claudette, Briles, David, Anderson, Porter
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology (ASM) 2001
Gaiak:	Microbial Immunity and Vaccines
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC98576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447162/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.8.4870-4873.2001
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Intranasal Immunization with Killed Unencapsulated Whole Cells Prevents Colonization and Invasive Disease by Capsulated Pneumococci

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