Intranasal Immunization with Killed Unencapsulated Whole Cells Prevents Colonization and Invasive Disease by Capsulated Pneumococci

A whole-cell killed unencapsulated pneumococcal vaccine given by the intranasal route with cholera toxin as an adjuvant was tested in two animal models. This vaccination was highly effective in preventing nasopharyngeal colonization with an encapsulated serotype 6B strain in mice and also conferred...

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Detalles Bibliográficos

Publicado en:	Infect Immun
Autores principales:	Malley, Richard, Lipsitch, Marc, Stack, Anne, Saladino, Richard, Fleisher, Gary, Pelton, Steven, Thompson, Claudette, Briles, David, Anderson, Porter
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2001
Materias:	Microbial Immunity and Vaccines
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC98576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447162/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.8.4870-4873.2001
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