Specific Antibodies to Porphyromonas gingivalis Lys-Gingipain by DNA Vaccination Inhibit Bacterial Binding to Hemoglobin and Protect Mice from Infection

Lys-gingipain (KGP), a lysine-specific cysteine proteinase, is one of the major virulence factors of Porphyromonas gingivalis. Here we examined the involvement of the catalytic domain of KGP (KGP(cd)) in hemoglobin binding by P. gingivalis, using a specific immunoglobulin G (IgG) elicited by the adm...

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Publié dans:	Infect Immun
Auteurs principaux:	Kuboniwa, Masae, Amano, Atsuo, Shizukuishi, Satoshi, Nakagawa, Ichiro, Hamada, Shigeyuki
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2001
Sujets:	Microbial Immunity and Vaccines
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC98250/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11292714/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.5.2972-2979.2001
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