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Specific Antibodies to Porphyromonas gingivalis Lys-Gingipain by DNA Vaccination Inhibit Bacterial Binding to Hemoglobin and Protect Mice from Infection

Lys-gingipain (KGP), a lysine-specific cysteine proteinase, is one of the major virulence factors of Porphyromonas gingivalis. Here we examined the involvement of the catalytic domain of KGP (KGP(cd)) in hemoglobin binding by P. gingivalis, using a specific immunoglobulin G (IgG) elicited by the adm...

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Autori principali: Kuboniwa, Masae, Amano, Atsuo, Shizukuishi, Satoshi, Nakagawa, Ichiro, Hamada, Shigeyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC98250/
https://ncbi.nlm.nih.gov/pubmed/11292714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.5.2972-2979.2001
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