Replacement of Histidine 340 with Alanine Inactivates the Group A Streptococcus Extracellular Cysteine Protease Virulence Factor

Streptococcus pyogenes expresses a highly conserved extracellular cysteine protease that is a virulence factor for invasive disease, including soft tissue infection. Site-directed mutagenesis was used to generate a His340Ala recombinant mutant protein that was made as a stable 40-kDa zymogen by Esch...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	Infect Immun
Principais autores:	Gubba, Siddeswar, Cipriano, Vincent, Musser, James M.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2000
Fag:	Molecular and Cellular Pathogenesis
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97664/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10816533/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.6.3716-3719.2000
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!