Gram-Positive Bacteria Are Potent Inducers of Monocytic Interleukin-12 (IL-12) while Gram-Negative Bacteria Preferentially Stimulate IL-10 Production

Interleukin-10 (IL-10) and IL-12 are two cytokines secreted by monocytes/macrophages in response to bacterial products which have largely opposite effects on the immune system. IL-12 activates cytotoxicity and gamma interferon (IFN-γ) secretion by T cells and NK cells, whereas IL-10 inhibits these f...

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Autores principales: Hessle, Christina, Andersson, Bengt, Wold, Agnes E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Host Response and Inflammation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC97646/
https://ncbi.nlm.nih.gov/pubmed/10816515
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