Helicobacter hepaticus Triggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism

Mice rendered deficient in interleukin-10 (IL-10) by gene targeting (IL-10(−/−) mice) develop chronic enterocolitis resembling human inflammatory bowel disease (IBD) when maintained in conventional animal facilities. However, they display a minimal and delayed intestinal inflammatory response when r...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Kullberg, Marika C., Ward, Jerrold M., Gorelick, Peter L., Caspar, Patricia, Hieny, Sara, Cheever, Allen, Jankovic, Dragana, Sher, Alan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Host Response and Inflammation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108643/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9784517/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.66.11.5157-5166.1998
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