Helicobacter hepaticus Triggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism

Mice rendered deficient in interleukin-10 (IL-10) by gene targeting (IL-10(−/−) mice) develop chronic enterocolitis resembling human inflammatory bowel disease (IBD) when maintained in conventional animal facilities. However, they display a minimal and delayed intestinal inflammatory response when r...

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Detalhes bibliográficos
Main Authors: Kullberg, Marika C., Ward, Jerrold M., Gorelick, Peter L., Caspar, Patricia, Hieny, Sara, Cheever, Allen, Jankovic, Dragana, Sher, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC108643/
https://ncbi.nlm.nih.gov/pubmed/9784517
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