Flavones inhibit the hexameric replicative helicase RepA

Helicases couple the hydrolysis of nucleoside triphosphates (NTPs) to the unwinding of double-stranded nucleic acids and are essential in DNA metabolism. Thus far, no inhibitors are known for helicases except heliquinomycin isolated from Streptomyces sp. As the three-dimensional structure of the hex...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Xu, Hai, Ziegelin, Günter, Schröder, Werner, Frank, Joachim, Ayora, Sylvia, Alonso, Juan Carlos, Lanka, Erich, Saenger, Wolfram
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97556/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11812837/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.24.5058
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