Flavones inhibit the hexameric replicative helicase RepA

Helicases couple the hydrolysis of nucleoside triphosphates (NTPs) to the unwinding of double-stranded nucleic acids and are essential in DNA metabolism. Thus far, no inhibitors are known for helicases except heliquinomycin isolated from Streptomyces sp. As the three-dimensional structure of the hex...

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Bibliografiska uppgifter
Huvudupphovsmän: Xu, Hai, Ziegelin, Günter, Schröder, Werner, Frank, Joachim, Ayora, Sylvia, Alonso, Juan Carlos, Lanka, Erich, Saenger, Wolfram
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2001
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC97556/
https://ncbi.nlm.nih.gov/pubmed/11812837
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