Flavones inhibit the hexameric replicative helicase RepA

Helicases couple the hydrolysis of nucleoside triphosphates (NTPs) to the unwinding of double-stranded nucleic acids and are essential in DNA metabolism. Thus far, no inhibitors are known for helicases except heliquinomycin isolated from Streptomyces sp. As the three-dimensional structure of the hex...

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Autors principals: Xu, Hai, Ziegelin, Günter, Schröder, Werner, Frank, Joachim, Ayora, Sylvia, Alonso, Juan Carlos, Lanka, Erich, Saenger, Wolfram
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2001
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC97556/
https://ncbi.nlm.nih.gov/pubmed/11812837
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