Extending the CD4(+) T-Cell Epitope Specificity of the Th1 Immune Response to an Antigen Using a Salmonella enterica Serovar Typhimurium Delivery Vehicle

We analyzed the CD4 T-cell immunodominance of the response to a model antigen (Ag), MalE, when delivered by an attenuated strain of Salmonella enterica serovar Typhimurium (SL3261*pMalE). Compared to purified MalE Ag administered with adjuvant, the mapping of the peptide-specific proliferative respo...

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Hlavní autoři: Lo-Man, Richard, Langeveld, Jan P. M., Dériaud, Edith, Jehanno, Muguette, Rojas, Marie, Clément, Jean-Marie, Meloen, Robert H., Hofnung, Maurice, Leclerc, Claude
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2000
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC97535/
https://ncbi.nlm.nih.gov/pubmed/10816447
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