Blockade of Costimulation Prevents Infection-Induced Immunopathology in Interleukin-10-Deficient Mice

Interleukin-10 (IL-10) is associated with inhibition of cell-mediated immunity and downregulation of the expression of costimulatory molecules required for T-cell activation. When IL-10-deficient (IL-10KO) mice are infected with Toxoplasma gondii, they succumb to a T-cell-mediated shock-like reactio...

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Main Authors: Villegas, Eric N., Wille, Ulrike, Craig, Linden, Linsley, Peter S., Rennick, Donna M., Peach, Robert, Hunter, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2000
Assuntos:
Fungal and Parasitic Infections
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC97495/
https://ncbi.nlm.nih.gov/pubmed/10768980
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