Reduced Virulence of HWP1-Deficient Mutants of Candida albicans and Their Interactions with Host Cells

The Candida albicans gene HWP1 encodes a surface protein that is required for normal hyphal development in vitro. We used mutants lacking one or both alleles of HWP1 to investigate the role of this gene in virulence. Mice infected intravenously with the homozygous hwp1 null mutant, CAL3, survived a...

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Pubblicato in:	Infect Immun
Autori principali:	Tsuchimori, Noboru, Sharkey, Laura L., Fonzi, William A., French, Samuel W., Edwards, John E., Filler, Scott G.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Fungal and Parasitic Infections
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97378/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10722594/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.4.1997-2002.2000
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