Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Production by Human Monocytes Involves the Raf-1/MEK1-MEK2/ERK1-ERK2 Pathway

During gram-negative sepsis, human monocytes are triggered to produce large quantities of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in response to endotoxin (lipopolysaccharide [LPS]). Several studies have identified signal transduction pathways that are activated by LPS,...

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Publié dans:	Infect Immun
Auteurs principaux:	van der Bruggen, Tjomme, Nijenhuis, Suzanne, van Raaij, Estia, Verhoef, Jan, Sweder van Asbeck, B.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1999
Sujets:	Host Response and Inflammation
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96660/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10417144/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.8.3824-3829.1999
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