Preliminary Assessment of the Safety and Immunogenicity of a New CTXΦ-Negative, Hemagglutinin/Protease-Defective El Tor Strain as a Cholera Vaccine Candidate

Vibrio cholerae 638 (El Tor, Ogawa), a new CTXΦ-negative hemagglutinin/protease-defective strain that is a cholera vaccine candidate, was examined for safety and immunogenicity in healthy adult volunteers. In a double-blind placebo-controlled study, no significant adverse reactions were observed in...

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Detalhes bibliográficos
Main Authors: Benítez, Jorge A., García, Luis, Silva, Anisia, García, Hilda, Fando, Rafael, Cedré, Barbara, Pérez, Antonio, Campos, Javier, Rodríguez, Boris L., Pérez, José L., Valmaseda, Tania, Pérez, Oliver, Pérez, Alberto, Ramírez, Margarita, Ledón, Talena, Jidy, Manuel Díaz, Lastre, Miriam, Bravo, Laura, Sierra, Gustavo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC96352/
https://ncbi.nlm.nih.gov/pubmed/9916056
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