Preliminary Assessment of the Safety and Immunogenicity of a New CTXΦ-Negative, Hemagglutinin/Protease-Defective El Tor Strain as a Cholera Vaccine Candidate

Vibrio cholerae 638 (El Tor, Ogawa), a new CTXΦ-negative hemagglutinin/protease-defective strain that is a cholera vaccine candidate, was examined for safety and immunogenicity in healthy adult volunteers. In a double-blind placebo-controlled study, no significant adverse reactions were observed in...

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Bibliografiska uppgifter
Huvudupphovsmän: Benítez, Jorge A., García, Luis, Silva, Anisia, García, Hilda, Fando, Rafael, Cedré, Barbara, Pérez, Antonio, Campos, Javier, Rodríguez, Boris L., Pérez, José L., Valmaseda, Tania, Pérez, Oliver, Pérez, Alberto, Ramírez, Margarita, Ledón, Talena, Jidy, Manuel Díaz, Lastre, Miriam, Bravo, Laura, Sierra, Gustavo
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 1999
Ämnen:
Microbial Immunity and Vaccines
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC96352/
https://ncbi.nlm.nih.gov/pubmed/9916056
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